Oxidative Stress, Plant-Derived Antioxidants and Liver Fibrosis

Abstract

There is accumulating evidence that oxidative stress plays a considerable role in the development of liver fibrosis by acting in different cell types and in different signaling pathways. Consequently, antioxidants, particularly those of plant origin, have emerged as potent antifibrotic agents. This review briefly summarizes current views of the mechanisms of fibrogenesis and recent findings on the antifibrotic potential of plant-derived antioxidants.

Antioxidants - fibrogenesis - flavonoids - hepatic stellate cells - reactive oxygen species

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