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Planta Med 2002; 68(4): 289-296
DOI: 10.1055/s-2002-26761
Review
© Georg Thieme Verlag Stuttgart · New York

Oxidative Stress, Plant-Derived Antioxidants and Liver Fibrosis

R. Gebhardt1
  • 1Institut of Biochemistry, University of Leipzig, Germany
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Publikationsverlauf

July 31, 2001

January 6, 2002

Publikationsdatum:
02. Mai 2002 (online)

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Abstract

There is accumulating evidence that oxidative stress plays a considerable role in the development of liver fibrosis by acting in different cell types and in different signaling pathways. Consequently, antioxidants, particularly those of plant origin, have emerged as potent antifibrotic agents. This review briefly summarizes current views of the mechanisms of fibrogenesis and recent findings on the antifibrotic potential of plant-derived antioxidants.

Key words

Antioxidants - fibrogenesis - flavonoids - hepatic stellate cells - reactive oxygen species

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Prof. Dr. Rolf Gebhardt

University of Leipzig

Medical Faculty

Institute of Biochemistry

Liebigstr. 16

04103 Leipzig

Germany

Fax: +49-341-9722109

eMail: rgebhardt@medizin.uni-leipzig.de