Semin Thromb Hemost 2002; 28(2): 203-214
DOI: 10.1055/s-2002-27822
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Successful Treatment of Patients with von Willebrand Disease using a High-Purity Double-Virus Inactivated Factor VIII/von Willebrand Factor Concentrate (Immunate®)

Günter Auerswald1 , Bruno Eberspächer2 , Werner Engl9 , Christiane Güthner8 , Marie Koksch3 , Wolfhart Kreuz4 , Antje Nimtz5 , Gerhard Pindur6 , Horst Scheel3 , Jörg D. Schreiber9 , Jürgen Siekmann9 , Peter L. Turecek9 , Hans-Heinrich Wolf7
  • 1Prof. Hess Kinderklinik, Bremen, Germany
  • 2Baxter Deutschland GmbH, Heidelberg, Germany
  • 3Klinik F. Innere Medizin, Universität Leipzig, Germany
  • 4Zentrum Kinderheilkunde, Johann Wolfgang Goethe-Universität, Frankfurt/Main, Germany
  • 5Kinderklinik Klinikum Frankfurt/Oder, Germany
  • 6Universitätsklinik des Saarlandes, Homburg/Saar, Germany
  • 7Klinik für Innere Medizin IV, Martin-Luther-Universität, Halle, Germany
  • 8Universitätsklinik und Poliklinik, Abt. Innere Medizin III, Ulm, Germany
  • 9Baxter AG, Vienna, Austria
Further Information

Publication History

Publication Date:
03 May 2002 (online)

ABSTRACT

Fourteen patients with different types of von Willebrand disease (vWD) having acute bleeds or elective surgery were treated with Immunate, a double-virus inactivated factor VIII/von Willebrand factor (FVIII/vWF) concentrate. The concentrate was applied as a bolus or via continuous infusion. FVIII activity (FVIIIc), vWF antigen (vWF:Ag), ristocetin cofactor activity (vWF:RCo), collagen binding activity (vWF:CB), activated partial thromboplastin time (aPTT), and von Willebrand multimers (vW-multimers) were monitored for 48 hours. Pharmacokinetic analyses were performed. The clinical efficacy was rated excellent or good. Bleeding complications occurred in 3 patients due to an additional FXIII deficiency in one patient, to a surgically induced bleed in another patient, and a rather short substitution period in the third patient. There were no serious adverse experiences. One patient showed a phlebitic reaction at the site of venous access after more than 100 hours of continuous infusion, requiring a change to application via bolus.

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