Synthesis 2002(7): 0937-0940
DOI: 10.1055/s-2002-28501
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart · New York

Indium(III) Complex-Catalyzed Tandem Carbonyl-Ene Reaction: An Efficient Construction of Tetrahydropyran Rings

Teck-Peng Loh*a, Li-Chun Fengb, Jian-Ying Yanga
a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
Fax: +(65)7791691; e-Mail: Chmlohtp@nus.edu.sg;
b Institute of Chemical Science, Ayer Rajah Crescent, Blk 28, 02-08, Singapore 139959
Further Information

Publication History

Received 1 March 2002
Publication Date:
14 May 2002 (online)

Abstract

An atom economic and efficient construction of tetrahydropyran rings using Indium triflate-catalyzed self-tandem carbonyl-ene, intramolecular (2,5) oxonium-ene cyclization between aldehydes and methylene cyclohexane is reported.