An Efficient Synthesis of Dimethylmaleic Anhydride

Sivaprakasam Mangaleswaran; Narshinha P. Argade

doi:10.1055/s-2002-28519

PAPER

An Efficient Synthesis of Dimethylmaleic Anhydride [1]

Sivaprakasam Mangaleswaran, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)5893153; e-Mail: argade@dalton.ncl.res.in;

Abstract

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Abstract

A facile three-step synthesis of dimethylmaleic anhydride (8) with 74% overall yield has been described starting from maleimide 1, via methylmaleimide 4, using two Wittig reactions followed by an alkaline hydrolysis.

Key words

maleic anhydride - maleimide, formaldehyde - condensation - alkylations - Wittig reactions

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References

References and Notes

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