Seminars in Vascular Medicine, Table of Contents Semin Vasc Med 2002; 2(2): 121-124DOI: 10.1055/s-2002-32035 EDITORIAL Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662 Low Protein Z Associated with Venous Thrombophilia and with Ischemic Stroke Jan Jacques Michiels The Goodheart Institute, Hemostasis Thrombosis Research and Vascular Medicine, Rotterdam, The Netherlands, and University Hospital Antwerp, Belgium Recommend Article Abstract Buy Article Full Text References REFERENCES 1 Michiels J J, Hamulyak K. Laboratory diagnosis of hereditary thrombophilia. Semin Thromb Hemost . 1998; 24 309-320 2 Huang Z-F, Higuchi D, Lasky N, Broze G J. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood . 1997; 90 944-951 3 Jalbert L R, Rosen E D, Moons L. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest . 1998; 102 1481-1488 4 Yin Z-F, Huang Z-F, Cui J. Prothrombotic phenotype of protein Z deficiency. PNAS . 2000; 97 6734-6738 5 Kemkes-Matthes B, Matthes K J. Protein Z. Semin Thromb Hemost . 2001; 27 551-556 6 Hogg P J, Stenflo J. Interaction of vitamin K-dependent protein Z with thrombin. J Biol Biochem . 1991; 266 10953-10958 7 Hogg P J, Stenflo J. Interaction of human protein Z with thrombin. Biochem Biophys Res Comm . 1991; 178 801-807 8 Kemkes-Matthes B, Matthes K J. Protein Z deficiency: a new cause of bleeding tendency. Thromb Res . 1995; 79 49-55 9 Gambda G, Bertilino G, Montani N, Spedini P, Balduini C L. Bleeding tendency of unknown origin and protein Z levels. Thromb Res . 1998; 90 291-295 10 Ravi S, Mauron T H, Lämmle B, Wuilleman W A. Protein Z in healthy human individuals and in patients with a bleeding tendency. Brit J Haematol . 1998; 102 1219-1223 11 Han X, Fiehler R, Broze G J. Isolation of a protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci USA . 1998; 95 9250-9255 12 Lopaciauk S, Bykowska K, Kwiecinsky H. Factor V Leiden, prothrombin G20210A variant, and methylenetetrahydrofolate reductase C677T genotype in young adults with ischemic stroke. Clin Appl Thromb Hemost . 2001; 7 346-350 13 Vasse M, Guegan-Massardier, Borg J-Y, Woimant F, Soria C. Frequency of protein Z deficiency in patients with ischaemic stroke. Lancet . 2001; 357 933-934