Abstract
The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid (1) and three galloyl glucoses (2 - 4). In addition, four flavonol glycoside gallates (5 - 8) from Euphorbia pekinensis containing the galloyl moiety also showed the inhibitory activity at a level comparable to those of 2 - 4. By comparison with the activities of the compounds not bearing this moiety, it is proposed that the galloyl moiety plays a major role for inhibition against the 3′-processing of HIV-1 integrase of these compounds.
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Prof. Jinwoong Kim
College of Pharmacy
Seoul National University
San 56-1, Shinlim-dong
Kwanak-gu, Seoul 151-742
Korea
Email: jwkim@snu.ac.kr
Fax: + 82 - 2-887 - 8509
