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Planta Med 2002; 68(5): 425-429
DOI: 10.1055/s-2002-32077
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Terpenoid and Immunosuppressive Phenolic Glycosides from the Root Bark of Dictamnus dasycarpus

Jun Chang1 , Li-Jiang Xuan1 , Ya-Ming Xu1 , Jin-Sheng Zhang1
  • 1Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China
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Publication History

July 10, 2001

October 28, 2001

Publication Date:
07 June 2002 (online)

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Abstract

Five new compounds, two degraded terpene glycosides, dasycarpusides A and B (1, 2), and three phenolic glycosides, 2-methoxy-4-hydroxymethylphenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (3), 2-methoxy-4-acetylphenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (4), and 2-methoxy-4-(8-hydroxyethyl)-phenol 1-O-α-rhamnopyranosyl-(1″→6′)-β-glucopyranoside (5), were isolated from the water-soluble constituents of the root bark of Dictamnus dasycarpus Turcz. (Rutaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. Moreover, it was found that dasycarpuside A (1) showed weak cytotoxic activity against A-549 (human lung adenocarcinoma) cell line, while 4 and 5 showed more remarkable activity of inhibiting the proliferation of T-cells in vitro.

Key words

Dictamnus dasycarpus - Rutaceae - dasycarpusides A and B - phenolic glycosides - cytotoxic activity - immunosuppressive activity

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Prof. Jin-Sheng Zhang

Shanghai Institute of Materia Medica

Shanghai Institutes for Biological Sciences

Chinese Academy of Sciences

294 Taiyuan Road Shanghai 200031

People’s Republic of China

Email: jszhang@mail.shcnc.ac.cn

Fax: +86-21-64370269