Defective Regulation and Action of Atrial Natriuretic Peptide in Type 2 Diabetes

M. Nannipieri; G. Seghieri; C. Catalano; T. Prontera; S. Baldi; E. Ferrannini

doi:10.1055/s-2002-32141

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2002; 34(5): 265-270
DOI: 10.1055/s-2002-32141

Original Clinical

Defective Regulation and Action of Atrial Natriuretic Peptide in Type 2 Diabetes

M. Nannipieri¹ , G. Seghieri¹ , C. Catalano¹ , T. Prontera¹ , S. Baldi¹ , E. Ferrannini¹

¹Metabolism Unit of the C. N. R. Institute of Clinical Physiology, and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy

Abstract

Increased plasma atrial natriuretic peptide (ANP) levels and impaired ANP action have been reported in patients with diabetes or insulin resistance. The aim of this study was to assess the interaction between insulin and ANP in type 2 diabetes. In 12 normotensive, normoalbuminuric type 2 diabetics, we infused insulin at a high (6.6 pmol/min/kg) or, on a different day, at a low rate (0.6 pmol/min/kg) during 4 hours of isoglycemia under isovolumic, isoosmolar conditions. The normal response was established in 12 healthy volunteers using an identical protocol. Despite higher baseline ANP levels (17.7 ± 2.8 vs. 10.8 ± 1.8 pg/ml, p = 0.04), urinary sodium excretion was similar in diabetics and controls (113 ± 8.5 vs. 102 ± 8.8 mEq/24 hours, p = ns). In both groups, hyperinsulinemia caused a decrease in blood volume (0.33 ± 0.10 l, p < 0.01), diastolic blood pressure (6 %, p < 0.02), and natriuresis. However, plasma ANP decreased in controls (from 12.7 ± 1.9 to 8.6 ± 1.4 pg/ml, p = 0.01) but not in type 2 diabetics (15.1 ± 2.7 vs. 17.2 ± 3.8 pg/ml, p = ns). We conclude that ANP release is resistant to volume stimulation in type 2 diabetic patients, and natriuresis is resistant to ANP action. This dual disruption of ANP control may play a role in blood pressure regulation in diabetes.

Key words

Atrial Natriuretic Peptide - Type 2 Diabetes - Hyperinsulinemia - Natriuresis

Full Text

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