Preeclampsia Associated With Antiphospholipid and Anti-β₂-Glycoprotein-I Antibodies and Postpartum Thrombocytopenia, Cardiac Dysfunction, and Blindness: A Case Report

Zusammenfassung

Fallbericht über eine Patientin mit schwerer Präeklampsie und postpartalen Komplikationen, bei der eine Palette von Autoimmunreaktionen auftrat.

Fallbericht

Eine 27-jährige erstmals Schwangere wurde nach 37-wöchiger Schwangerschaft mit schwerer Präeklampsie eingewiesen. Es wurde ein Kaiserschnitt vorgenommen. Postpartal trat eine gravierende Herzfunktionsstörung auf, sowie eine Thrombozytopenie, Anfälle von Eklampsie und Erblindung. Immunohistochemische Plazenta-Untersuchungen ergaben eine deutliche Ablagerung von terminalem C5b-9 Komplementkomplex im intervillösen Fibrin und intervillösen Ovarialstroma.

Schlussfolgerung

An der Pathogenese der Präeklampsie-Eklampsie kann die Entstehung von C5b-9 Komplementkomplex beteiligt sein.

Abstract

We describe a patient with severe preeclampsia and postpartum complications in whom we investigated a panel of autoimmune reactions.

Case Report

A 27-year-old primigravida was referred at 37 weeks' gestation because of severe preeclampsia. A cesarean section was performed. Postpartum the patient developed severe cardiac dysfunction, thrombocytopenia, eclamptic seizures, and blindness. Immunohistochemical studies of the placenta showed marked deposition of terminal C5b-9 complement complex in intervillous fibrin and in intravillous stroma.

Conclusion

The generation of C5b-9 complement complex may be involved in the pathogenesis of preeclampsia-eclampsia.

Schlüsselwörter

Präeklampsie - Antiphospholipidsyndrom - β₂-GPI-Antikörper - Komplementkomplex C5b-9

Key words

Preeclampsia - Antiphospholipid syndrome - β₂-GPI antibodies - Complement complex C5 b-9

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