Zusammenfassung
Die medikamentöse Behandlung von Epilepsien ist ein Schwerpunktgebiet der Neurologie,
das nicht nur in spezialisierten Zentren von Bedeutung ist, sondern auch von niedergelassenen
Kollegen häufige und wichtige therapeutische Entscheidungen erfordert. Die Wahl des
richtigen Antikonvulsivums ist nicht immer einfach zu treffen, da sich die Möglichkeiten
durch die Neuentwicklung zahlreicher Substanzen in den letzten 10 Jahren sehr erweitert
haben. Dadurch ergeben sich neue Therapiestrategien, die eine differenziertere Einzeltherapie
ermöglichen, als es durch die bisher verhältnismäßig wenigen am Markt zugelassenen
Substanzen möglich war. Die neuen Substanzen zeichnen sich insgesamt durch bessere
Verträglichkeit und geringere Nebenwirkungen aus, allerdings ist eine genauere Kenntnis
der Wirkungs- und Nebenwirkungsprofile erforderlich. Die Pharmakologie, Pharmakokinetik,
Indikation, Dosierung und Nebenwirkungen der einzelnen Substanzen werden kurz zusammengefasst
diskutiert.
Abstract
The pharmacological treatment of epilepsies represents an important domain of neurological
therapeutical strategies and is not only important for specialized epilepsy centres,
but for all hospital -and office-based neurologists. The choice of the right anticonvulsive
drug is not always simple since the development of new drugs during the last 10 years
offers a broad range of possibilities. Therefore, pharmacological treatment has become
more sophisticated than it was with relatively few anticonvulsive drugs before. The
new drugs are better tolerated and have less side effects, but more knowledge is required
about the specific aspects of each drug. Pharmacology, pharmacocinetics, indication,
dosage and side effects of the substances will be summarized and discussed.
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91054 Erlangen
