Inhibitory Effects of Natural Sesquiterpenoids Isolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E₂ and Nitric Oxide Production

Abstract

β-Turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglandin E₂ production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC₅₀ = 7.3 μM for β-turmerone; IC₅₀ = 24.0 μM for ar-turmerone). In addition, these compounds exhibited inhibitory effects on LPS-induced nitric oxide production in the cell system.

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