Aceriphyllic Acid A, A New ACAT Inhibitory Triterpenoid, from Aceriphyllum rossii

Abstract

Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3α-hydroxyolean-12-en-27-oic acid (2) and 3β-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3α,23-dihydroxyolean-12-en-27-oic acid (4) and a 3α,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.

References

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