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DOI: 10.1055/s-2002-32566
Phagnalon rupestre as a Source of Compounds Active on Contact Hypersensitivity
Publikationsverlauf
June 25, 2001
January 20, 2002
Publikationsdatum:
01. Juli 2002 (online)
Abstract
The effect of Phagnalon rupestre MeOH extract on dinitrofluorobenzene- and sheep red blood cells-induced hypersensitivity was investigated. Eight compounds were identified: three dimethylallyl-hydroquinone glucosides (1 - 3), 3,5- and 4,5-di-O-caffeoylquinic acid methyl esters (4 and 5), their free carboxyl analogues (6 and 7), and luteolin 7-O-β-glucoside (8). All were tested for dinitrofluorobenzene-induced contact hypersensitivity inhibitory activity. Flavonoid 8 was the most active (49 % and 79 % inhibition at 24 and 96 h, respectively). The hydroquinones 1, 2 and 3 were effective at 96 h after challenge (62 %, 73 % and 60 % inhibition, respectively), while some of the dicaffeoylquinic derivatives (4 and 7) produced slightly lower reduction of the inflammatory reaction.