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DOI: 10.1055/s-2002-32888
Antiplasmodial Activity of Labdanes from Aframomum latifolium and Aframomum sceptrum
Publikationsverlauf
Received: October 2, 2001
Accepted: December 5, 2001
Publikationsdatum:
22. Juli 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200207/lookinside/thumbnails/10.1055-s-2002-32888-1.jpg)
Abstract
Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-(S)-nerolidol and seven labdanes, coronarin B, galanal A and B, galanolactone, (E)-8β,17-epoxylabd-12-ene-15,16-dial, (+)-(E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact. The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.
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Dr. Søren Brøgger Christensen
Department of Medicinal Chemistry
Royal Danish School of Pharmacy
Universitetsparken 2
DK-2100 Copenhagen
Denmark
eMail: sbc@dfh.dk
Fax: +45 3530 6040