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DOI: 10.1055/s-2002-32893
Bioactive Sesquiterpene Lactones from Centaurea Species and their Cytotoxic/Cytostatic Activity Against Human Cell Lines in vitro
Publikationsverlauf
Received: October 5, 2001
Accepted: January 20, 2002
Publikationsdatum:
22. Juli 2002 (online)
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Abstract
Sesquiterpene lactones isolated from the aerial parts of various species of the genus Centaurea were examined for their in vitro cytotoxic/cytostatic activity against five human cell lines (i. e., DLD1, SF268, MCF7, H460 and OVCAR3). Compounds 1 - 4 were isolated from C. zuccariniana, 5 and 6 from C. achaia, 7 from C. thessala ssp. drakiensis and compounds 8 and 9 from C. deusta. Compound 1, 8α-O-(3,4-dihydroxy-2-methylenebutanoyloxy)dehydromelitensine was found to be the most active, exhibited a considerable growth inhibiting activity against three of the cell lines tested, while compound 5 8α-O-(3-hydroxy-2-methylenepropanoyl)dehydromelitensin exhibited a growth inhibiting effect against most of the tested cell lines. A new eudesmanolide (8α-hydroxysonchucarpolide, 4) was isolated from C. zuccariniana and its structure was elucidated by spectroscopic methods.
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Prof. Dr. Assist. H Skaltsa
University of Athens
School of Pharmacy
Division of Pharmacognosy
Panepistimiopolis
Zografou
GR-157 71 Athens
Greece
eMail: skaltsa@pharm.uoa.gr
Fax: +30108613965
Telefon: +30107274593