Endoscopy 2002; 34(7): 582-584
DOI: 10.1055/s-2002-33213
Case Report
© Georg Thieme Verlag Stuttgart · New York

Endoscopic Treatment of Esophageal Granular Cell Tumors

F.  Catalano 1 , R.  Kind 1 , L.  Rodella 1 , F.  Lombardo 1 , M.  Festini 1 , A.  Tomezzoli 2 , G.  de Manzoni 1
  • 1Servizio di Chirurgia Endoscopica d'Urgenza, I Divisione Clinicizzata di Chirurgia Generale, Università degli Studi di Verona, Verona, Italy
  • 2Instituto di Istologia ed Anatomia Patologica, Ospedale Civile Maggiore di Verona, Verona, Italy
Further Information

Publication History

Submitted 14 August 2001

Accepted after Revision 19 February 2002

Publication Date:
12 August 2002 (online)

There are no standard guidelines for the treatment of granular cell tumor (GCT). The aim of our study was to describe three cases of esophageal GCT and, on the basis of our experience, analyze the indications for and results of their endoscopic treatment. When deciding whether to proceed with surgical or endoscopic resection, endosonography plays a key role in establishing whether the tumor is confined to the submucosa. All three cases were confined within the hyperechoic layer of the submucosa and were successfully treated by endoscopic excision without complications or signs of relapse during the follow-up period.

References

  • 1 Abrikossoff A I. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur.  Virchows Arch (Pathol Anat). 1926;  260 215
  • 2 Nathrath W BJ, Remberg K. Immunohistochemical study of granular cell tumor. Demonstration of neuron specific enolase, S-100 protein, lamin and alpha-1-antichymotrypsin.  Virchows Arch A. 1986;  408 421-434
  • 3 Billeret Lebranchu V. Granular cell tumor. Epidemiology of 263 cases.  Arch Anat Cytol Pathol. 1999;  47 26-30
  • 4 Strong E W, McDivitt R W, Brasfield R D. Granular cell myoblastoma.  Cancer. 1970;  25 415-422
  • 5 Tada S, Iida M, Yao T. et al . Granular cell tumor of the esophagus: endoscopic ultrasonographic demonstration and endoscopic removal.  Am J Gastroenterol. 1990;  85 1507-1511
  • 6 Esaki M, Aoyagi K, Hizawa K. et al . Multiple granular cell tumors of the esophagus removed endoscopically: a case report.  Gastrointest Endosc. 1998;  48 536-539
  • 7 Kawamoto K, Yamada Y, Furukawa N. et al . Endoscopic submucosal tumorectomy for gastrointestinal submucosal tumors restricted to the submucosa: a new form of endoscopic minimal surgery.  Gastrointest Endosc. 1997;  46 311-317
  • 8 Goldblum J R, Rice T W, Zuccaro G, Richter J E. Granular cell tumor of the esophagus: a clinical and pathologic study of 13 cases.  Am Thorac Surg. 1996;  62 860-865
  • 9 Snobe H, Iwata J, Furihata M. et al . Malignant granular cell tumor: report of a case and review of the literature.  Pathol Res Pract. 1988;  194 507-513
  • 10 Yasuda I, Tomita E, Nagura K. et al . Endoscopic removal of granular cell tumors.  Gastrointest Endosc. 1995;  41 63-67

F. Catalano, M.D.

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