Hyrtiosanes from Labdanes: (-)-Hyrtiosal from Sclareol

Abstract

(-)-Hyrtiosal and its C-16 epimer have been prepared from sclareol in moderate yield. The absolute configuration of na­tural product (-)-hyrtiosal has being determined.

Key words

terpenoids - labdanes - hyrtiosal - sclareol - natural products - coupling - antitumor agents

References

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7

Crystallographic data (excluding structure factors) for the structures in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC 145607. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone]; e-mail: [e-mail].