Synthesis of 2-(3-Hydroxypropyl)indol-3-acetic Acid and 3-(2-Hydroxy­ethyl)indole-2-propanoic Acid by Selective Functional Group Transformations

Sophie-Isabelle  Bascop; Jean-Yves  Laronze; Janos  Sapi

doi:10.1055/s-2002-33642

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Synthesis 2002(12): 1689-1694
DOI: 10.1055/s-2002-33642

PAPER

Synthesis of 2-(3-Hydroxypropyl)indol-3-acetic Acid and 3-(2-Hydroxyethyl)indole-2-propanoic Acid by Selective Functional Group
Transformations

Sophie-Isabelle Bascop, Jean-Yves Laronze, Janos Sapi*
Laboratoire de Chimie Thérapeutique, UMR 6013 du CNRS ‘Isolement, Structure, Transformations et Synthèse de Produits Naturels’, IFR 53 ‘Biomolécules’, Faculté de Pharmacie, Université de Reims-Champagne-Ardenne, 51096 Reims, Cedex, France
Fax: +33(3)26918029; e-Mail: janos.sapi@univ-reims.fr;

Further Information

Publication History

Received 27 March 2002
Publication Date:
05 September 2002 (online)

Abstract
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Abstract

Hydroxyalkylindolyl acetic(propanoic) acids 1 and 2 were prepared from a common intermediate dimethyl ester 3 by chemoselective hydrolyses and reductions.

Key words

chemoselectivity - hydrolysis - reduction - indol-3-acetic acid - indole-2-propanoic acid

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