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Synthesis 2002(12): 1649-1651
DOI: 10.1055/s-2002-33649
DOI: 10.1055/s-2002-33649
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Primary Thioamides
from Nitriles and Hydrogen Sulfide
Catalyzed by Anion-Exchange
Resin
Further Information
Publication History
Received
22 March 2002
Publication Date:
05 September 2002 (online)


Abstract
A new method has been developed for converting nitriles into primary thioamides. Treatment of various nitriles (Table [1] , entries 1-12) with gaseous hydrogen sulfide in a mixture of methanol-water or ethanol-water and in the presence of anion-exchange resin (Dowex 1X8, SH- form) at room temperature and ambient pressure gave the corresponding thioamides in 25-96% yield.
Key words
thioamides - addition reactions - nitriles - nucleosides - ion exchange resins