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Synthesis 2002(12): 1643-1645
DOI: 10.1055/s-2002-33656
DOI: 10.1055/s-2002-33656
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Efficient Synthesis of
Optically Active 2,3-Allenols via the Simple
CuBr-Mediated
Reaction of Optically Active Propargylic Alcohols
with
Paraformaldehyde
Further Information
Received
16 April 2002
Publication Date:
05 September 2002 (online)
Publication History
Publication Date:
05 September 2002 (online)
Abstract
Enantiomerically enriched 2,3-allenols were prepared by the CuBr-mediated homologation of the relatively easily available optically active terminal propargylic alcohols with paraformaldehyde in the presence of diisopropylamine.
Key words
propargylic alcohols - 2,3-allenols - copper
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