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Planta Med 2002; 68(8): 745-747
DOI: 10.1055/s-2002-33789
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Sesquiterpene Lactones from Carpesium abrotanoides

JunSung Lee1 , ByungSun Min2 , SangMyung Lee2 , MinKyun Na1 , ByungMok Kwon2 , ChongOck Lee3 , YoungHo Kim1 , KiHwan Bae1
  • 1College of Pharmacy, Chungnam National University, Taejon, Korea
  • 2Korea Research Institute of Bioscience & Biotechnology, Taejon, Korea
  • 3Korea Research Institute of Chemical Technology, Teajon, Korea
Further Information

Publication History

Received: October 22, 2001

Accepted: March 17, 2002

Publication Date:
09 September 2002 (online)

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Abstract

Eight sesquiterpene lactones, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 μM) against all tumor call lines tested. Among these compounds, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 μM) comparable to that of cisplatin.

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Prof. KiHwan Bae

College of Pharmacy

Chungnam National University

Taejon 305-764

Korea

Email: baekh@cnu.ac.kr

Fax: +82-42-823-6566