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DOI: 10.1055/s-2002-33799
Anti-trypanosomal Activity of Helenalin and Some Structurally Related Sesquiterpene Lactones
Publication History
Received: October 19, 2001
Accepted: February 24, 2002
Publication Date:
09 September 2002 (online)
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Abstract
The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11α,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T. cruzi was investigated. All tested compounds were found active towards both parasites, the former being generally more sensitive. Helenalin was the most active compound in the series with IC50 values of 0.051 and 0.695 μM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation.
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Priv.-Doz. Dr. Thomas J. Schmidt
Institut für Pharmazeutische Biologie
Heinrich-Heine-Universität Düsseldorf
Universitätsstrasse 1, Geb. 26.23
40225 Düsseldorf, Germany
Phone: +49-211-8114179
Fax: +49-211-8111923
Email: e-mail: schmidtt@uni-duesseldorf.de