Planta Med 2002; 68(8): 757-759
DOI: 10.1055/s-2002-33808
Letter
© Georg Thieme Verlag Stuttgart · New York

Variation in Content of Taxol and Related Taxanes in Eastern Himalayan Populations of Taxus wallichiana

Swapna Mukherjee1 , Biswajit Ghosh2 , Timir. B. Jha3 , Sumita Jha1
  • 1Centre of Advanced Study, Department of Botany, University of Calcutta, Calcutta, India
  • 2RKMVC College, Rahara, W.B., India
  • 3Darjeeling Govt. College, Darjeeling, W.B., India
Further Information

Publication History

Received: October 23, 2001

Accepted: March 17, 2002

Publication Date:
09 September 2002 (online)

Abstract

Extraction and analysis of paclitaxel and other taxanes in bark, needle leaves and stem segments of male and female plants of Taxus wallichiana, representing several populations, indicate that significant variation in taxane content exists within the population. Bark accumulated maximum amount of paclitaxel in almost all plants. Populations located at higher altitude tended to accumulate more paclitaxel than lower altitude plants. Seasons in which samples were collected and plant age have also been shown to affect paclitaxel accumulation. No effects of plant sex on paclitaxel content of the plants analyzed were observed. Significant differences in baccatin-III and 10-deacetylbaccatin III content were found to exist in the trees analyzed in this study.

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Sumita Jha

Centre of Advanced Study

Department of Botany

University of Calcutta

35, Ballygunge Circular Road

Calcutta 700 019

India

Email: sumita.jha@vsnl.com