Abstract
The aim of this experimental study was to verify the biocompatibility of a new bone glue in a fracture model in rabbits. The fracture healing after the glue application and osseointegration were to be analyzed through histological and radiological invastigations. 36 rabbits were operated unifemoral and observed over a period of 7, 21, 42 and 84 days. The bone glue in its characteristics, has a good biocompatibility without any inflammatory tissue reaction and a good absorption. A regular fracture healing after adequate reduction can be observed, without being a barrier for cellular migration and osteogenesis.
Key words
Bone glue - methacrylates - biocompatibility - histological light microscopy - experimental study
References
-
1
Donath K.
Die Trenn-Dünnschliff-Technik zur Herstellung histologischer Präparate von nicht schneidbaren Geweben und Materialien.
Der Präparator.
1988;
34
197-206
-
2
Donkerwolcke M, Burney F, Muster D.
Tissues and bone adhesives - historical aspects.
Biomaterials.
1998;
19
1461-1466
-
3
Mueller M E.
Die Verwendung von Kunstharzen in der Knochenchirurgie.
Archiv für orthopädische und Unfall-Chirurgie.
1962;
54
513-522
-
4
Weber S C, Chapman M W.
Adhesives in orthopaedic surgery. A review of the literature and in vitro bonding strengths of bone-bonding agents.
Clin Orthop.
1984;
191
249-261
-
5 Wenz R. First Results with a Bioresorbable Bone Glue. Biomaterials in Surgery. Walenkamp GHIM (ed). Thieme, Stuttgart 1998; 132-135
Christian HeissM.D.
Department of Trauma Surgery, Justus-Liebig-University Giessen
(Laboratory of Experimental Trauma Surgery)
Rudolf-Buchheim-Strasse 7
35385 Giessen
Germany
Phone: +49/6 41/9 94 46 00
Fax: +49/6 41/9 94 46 09
Email: christian.heiss@chiru.med.uni-giessen.de
