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Synthesis 2002(13): 1885-1890
DOI: 10.1055/s-2002-33914
DOI: 10.1055/s-2002-33914
PAPER
© Georg Thieme Verlag Stuttgart · New York
Asymmetric Synthesis of Densely Functionalized Pyrazolidines and 1,3-Diamines
Further Information
Received
1 June 2002
Publication Date:
09 September 2002 (online)
Publication History
Publication Date:
09 September 2002 (online)
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Abstract
A versatile and straightforward access to polysubstituted 1,3-diamines with good control of relative and absolute configurations is described. The key steps involve a diastereoselective 1,3-dipolar cycloaddition of a chiral non-racemic azomethine imine ylide and a chemoselective electroreduction of densely functionalized pyrazolidines intermediates.
Key words
asymmetric synthesis - cycloadditions - ylides - reductions - chemoselectivity
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