Zusammenfassung
Infektionen durch Enteritis-Salmonellen verlaufen bei immunsupprimierten Patienten
häufiger als bei Gesunden mit extraintestinalen Manifestationen. In etwa 25 % handelt
es sich dabei um septische Arthritiden. Besonders disponiert sind Patienten mit systemischem
Lupus erythematodes. Wir berichten über eine Gonarthritis durch Salmonella enteritidis
bei einer 16-jährigen Patientin. Eine erschwerte und verzögerte Diagnosestellung aufgrund
ähnlicher Symptome der Grunderkrankung und der septischen Arthritis führte trotz systemischer
antibiotischer Therapie zu einer Destruktion des Gelenkes. Sieben Monate nach Diagnosestellung
wurde erfolgreich eine Kniegelenksendoprothese eingesetzt. Frühzeitige Diagnosestellung,
adäquate Antibiotika-Therapie und gegebenenfalls eine chirurgische Intervention sind
essenziell für eine erfolgreiche Behandlung. Daher ist es wichtig, bei diesen Patienten,
wenn sie unter anderem über Fieber oder Gelenkbeschwerden klagen, auch an Infektionen
und speziell an Salmonellosen zu denken.
Abstract
Extraintestinal manifestations of Salmonella infection occur more frequently in immunocomprimised
patients than in healthy persons. About 25 % present as septic arthritis. Particularly
patients with SLE are predisposed. We report a case of a 16-year old girl with systemic
lupus erythematosus who developed septic arthritis of the left knee. Delayed diagnosis
because of similar symptoms of arthritis due to lupus and purulent arthritis led to
a destruction of the joint despite systemic antibiotic treatment. Seven months later
an endoprothesis was implanted with good outcome. Early diagnosis, adequate antibiotic
therapy and, if necessary, surgical intervention are essential for successful treatment.
In patients with SLE suffering from fever or arthritis it is necessary to think of
infections particularly due to salmonella.
Schlüsselwörter
Salmonella enteritidis - systemischer Lupus erythematodes - Arthritis
Key words
Salmonella enteritidis - Systemic lupus erythematosus - Arthritis
Literatur
1
Abramson S, Kramer S B, Radin A, Holzman R.
Salmonella bacteremia in systemic lupus erythematosus. Eight-year experience at a
municipal hospital.
Arthritis Rheum.
1985;
28
75-79
2
Adeyokunnu A A, Hendrickse R G.
Salmonella osteomyelitis in childhood. A report of 63 cases seen in Nigerian children
of whom 57 had sickle cell anaemia.
Arch Dis Child.
1980;
55
175-184
3
Aznar C P.
Fulminant soft tissue infection by salmonella enteritidis in SLE.
J Rheumatol.
1990;
17
1570-1571
4
Broucke I, Ruben F I, Hogg J P.
Salmonella vertebral osteomyelitis in an normal host following minor trauma.
Complications in Surgery.
1992;
9
46-49
5
Carroll W L, Balistreri W F, Brilli R, Parish R A, Greenfield D J.
Spectrum of Salmonella associated arthritis.
Pediatrics.
1981;
68
717-720
6
Chen J Y, Luo S F, Wu Y J, Wang C M, Ho H H.
Salmonella septic arthritis in systemic lupus erythematosus and other systemic diseases.
Clin Rheumatol.
1998;
17
282-287
7
Frayha R A, Jizi I, Saadeh G.
Salmonella typhimurium bacteriuria. An increased infection rate in systemic lupus
erythematosus.
Arch Intern Med.
1985;
145
645-647
8
Hammoudeh M, Siam A R.
Salmonella peritonitis and splenic abscess in a patient with systemic lupus erythematosus.
Ann Rheum Dis.
1992;
51
140
9
Kamarulzaman A, Briggs R J, Fabinyi G, Richards M J.
Skull osteomyelitis due to Salmonella species: two case reports and review.
Clin Infect Dis.
1996;
22
638-641
10
Laar M A, Meenhorst P L, van Soesbergen R M, Olsthorn P G, van der Korst J K.
Polyarticular salmonella bacterial arthritis in a patient with systemic lupus erythematosus.
J Rheumatol.
1989;
16
231-234
11
Le C T.
Salmonella vertebral osteomyelitis: a case report with literature review.
Am J Dis Child.
1982;
136
722-724
12
Li E K, Cohen M G, Ho A K, Cheng A F.
Salmonella bacteraemia occurring concurrently with the first presentation of systemic
lupus erythematosus.
Br J Rheumatol.
1993;
32
66-67
13
Madan S, Abbas D, Jowett R L, Mounce K.
Salmonella enteritidis infection in total knee replacement.
Rheumatology (Oxford).
2001;
40
112-113
14
Martinez Lacasa J T, Palacin A V, Ferranz V P, Sampere I M, Cerezales M S, Fernandez
Nogues F.
Systemic lupus erythematosus presenting as Salmonella enteritidis bacteremia.
J Rheumatol.
1991;
18
785
15
Medina F, Fraga A, Lavalle C.
Salmonella septic arthritis in systemic lupus erythematosus. The importance of chronic
carrier state.
J Rheumatol.
1989;
16
203-208
16
Potter M, Walko E.
Back pain in an eight-year-old.
Pediatr Infect Dis J.
1992;
11
241-250
17
Roy S, Tan K T.
Pyrexia and normal C-reactive protein (CRP) in patients with systemic lupus erythematosus:
always consider the possibility of infection in febrile patients with systemic lupus
erythematosus regardless of CRP levels.
Rheumatology.
2001;
40
349-350
18
Sanchez-Guerrero J, Alarcon-Segovia D.
Salmonella pericarditis with tamponade in systemic lupus erythematosus.
Br J Rheumatol.
1990;
29
69-71
19
Santos E M, Sapico F L.
Vertebral osteomyelitis due to salmonellae: report of two cases and review.
Clin Infect Dis.
1998;
27
287-295
20
Shahram F, Akbarian M, Davatchi F.
Salmonella infection in systemic lupus erythematosus.
Lupus.
1993;
2
55-59
21
ter Borg E J, Horst G, Limburg P C, van Rijswijk M H.
C-reactive protein levels during disease exacerbations and infections in systemic
lupus erythematosus: A prospective longitudinal study.
J Rheumatol.
1990;
17
1642-1648
22
van Cappelle H G, Veenendaal D, de Vogel P L.
Salmonella panama osteomyelitis in an otherwise healthy patient. A case report.
Clin Orthop.
1995;
12
235-238
Dr. Michael Borte
Universitätsklinik und Poliklinik für Kinder und Jugendliche
Oststraße 21-25
04317 Leipzig
Phone: 03 41/9 72 60 65
Fax: 03 41/9 72 60 39
Email: mborte@medizin.uni-leipzig.de