Psychiatr Prax 2002; 29(6): 318-320
DOI: 10.1055/s-2002-34039
Kasuistik
© Georg Thieme Verlag Stuttgart · New York

Manifestation eines Diabetes mellitus unter Therapie mit Olanzapin

Olanzapine-Induced Diabetes MellitusRalf  Kozian1
  • 1Landesklinik Brandenburg
Further Information

Publication History

Publication Date:
11 September 2002 (online)

Zusammenfassung

Eine potenzielle Nebenwirkung der Olanzapintherapie ist die Manifestation eines Diabetes mellitus. Mögliche pathogenetische Mechanismen werden diskutiert, wobei der Minderung der Insulinempfindlichkeit infolge einer Gewichtszunahme entsprechend der Datenlage die größte Relevanz zukommt.

Abstract

A potential side-effect in the treatment with olanzapine is hyperglycemia or new onset diabetes mellitus. There are possible mechanisms by which olanzapine could interfere with glucose metabolism but decreased insulin sensitivity due to weight gain is of most relevance.

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Dr. Ralf Kozian

Landesklinik Brandenburg

Anton-Saefkow-Allee 2

14772 Brandenburg