Endoscopy 2002; 34(10): 840-841
DOI: 10.1055/s-2002-34272
Case Report

© Georg Thieme Verlag Stuttgart · New York

Ulcerative Colitis in a Patient with Wiskott-Aldrich Syndrome

C.  Folwaczny 2 , C.  Ruelfs 1 , J.  Walther 1 , A.  König 1 , B.  Emmerich 1
  • 1Medizinische Klinik, Ludwig-Maximilians-Universität, Munich, Germany
  • 2Medizinische Poliklinik, Ludwig-Maximilians-Universität, Munich, Germany
Further Information

Publication History

Received: 7 March 2002

Accepted after Revision: 17 April 2002

Publication Date:
23 September 2002 (online)

A 30-year-old man with underlying Wiskott-Aldrich syndrome, which is a rare X-linked congenital immunodeficiency syndrome characterized by recurrent infections, thrombopenia, eczema and hematopoietic malignancies, presented with bloody diarrhea. Endoscopic and histological evaluation was compatible with ulcerative colitis. Congenital immune defects are paralleled by enterocolitis mimicking inflammatory bowel disease in a substantial number of patients. Despite therapy with prednisolone and 5-ASA compounds, the patient described here experienced a relapse of the colitis twice. Subsequently a JC virus infection of the central nervous system was diagnosed, and he died due to progressive multifocal leukencephalopathy.

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C. Folwaczny, M.D.

Medizinische Poliklinik Innenstadt · Ludwig-Maximilians-Universität München

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Email: Christian.Folwaczny@medinn.med.uni-muenchen.de