Mechanistic Observations on the Unusual Reactivity of Dioxenone Photosubstrates­ in the Synthesis of Ingenol

Abstract

The irradiation of allylically substituted dioxenone photosubstrates 6 and 21 lead to unexpected products, the formation of which can be explained by a series of transannular hydrogen atom abstractions.

photochemistry - natural products - rearrangements - radicals - cycloadditions

References

1

Current address: Millennium Pharmaceuticals, Cambridge, MA, USA.

2

Current address: Department of Chemistry, University of Edinburgh, UK.

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