An efficient three-step procedure has been developed for synthesis
of β-tosylethylhydroxylamine from commercially available
starting material. This compound forms hydroxamic acids which undergo
amidyl radical-olefin cyclizations promoted by diethyl chlorophosphite
to give functionalized β-tosylethyl-protected lactams,
which can be deprotected under mild basic conditions.
lactams - radical reactions - protecting groups - cyclizations
