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DOI: 10.1055/s-2002-34384
Heterogeneous Catalysis: Ni/C-Catalyzed Cross-Couplings en route to Allylated Aromatics: Application to a Precursor to Coenzyme Q10
Publikationsverlauf
Publikationsdatum:
26. September 2002 (online)
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Abstract
The readily available, heterogeneous, and inexpensive catalyst nickel-on-charcoal (Ni/C) can be used to mediate couplings between vinyl alanes and benzylic chlorides under very mild conditions and in good yields. Although such allylated aromatics are themselves important compounds, as demonstrated in this work, their syntheses under the ‘green chemistry’ conditions used can smoothly arrive at precursors to valued quinone natural products, such as the nutraceutical coenzyme Q10.
Key words
heterogeneous catalysis - nickel-on-charcoal - cross-couplings - allylated aromatics - coenzyme Q10
- For a related study using Ni(0) under homogeneous conditions, see:
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References
Lipshutz, B. H.; Mollard, P.; Pfeiffer, S. S.; Chrisman, W., submitted.
8Lipshutz, B. H.; Tasler, S.; Chrisman, W.; Spliethoff, B.; Tesche, B. J. Org. Chem. in press.