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DOI: 10.1055/s-2002-34400
Effects of Chronic Chrysin Treatment in Spontaneously Hypertensive Rats
Publikationsverlauf
Received: December 10, 2001
Accepted: March 29, 2002
Publikationsdatum:
30. September 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200209/lookinside/thumbnails/10.1055-s-2002-34400-1.jpg)
Abstract
The effects of an oral daily dose (20 mg kg-1) of the flavonoid chrysin for 6 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. Chrysin reduces SHR elevated blood pressure, cardiac hypertrophy and functional vascular changes, but is without effect in WKY. These protective effects were associated with a reduced oxidative status due to the antioxidant properties of the drug.
Abbreviations
MDA:total plasma malondialdehyde
SBP:systolic blood pressure
SHR:spontaneously hypertensive rat
WKY:Wistar Kyoto rat
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Prof. Dr. Juan Duarte
Department of Pharmacology
School of Pharmacy
University of Granada
18071 Granada
Spain
Telefon: +34-958243889
Fax: +34-958248964
eMail: jmduarte@ugr.es