Abstract
A new method using direct on-line coupling between HPLC and UV-DAD/MS was developed
for the rapid detection of aristolochic acid I in plant preparations. The use of both
UV-DAD and MS detectors enables this method to be very selective. A ng range detection
limit was determined for both UV and MS detections. A quantitative determination of
aristolochic acid I in plant preparations was achieved using UV and MS detection.
A thin layer chromatography assay was also developed for the preliminary detection
of aristolochic acid I in complex mixtures.
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Prof. Dr. K. Hostettmann
Institut de Pharmacognosie et Phytochimie
B.E.P.
1015 Lausanne
Switzerland
Email: Kurt. Hostettmann @ipp.unil.ch
Fax: +41-021/692 45 65
