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DOI: 10.1055/s-2002-34418
Cucurbitacins from Trichosanthes kirilowii as the Inhibitory Components on Tyrosinase Activity and Melanin Synthesis of B16/F10 Melanoma Cells
Publication History
Received: February 8, 2002
Accepted: May 11, 2002
Publication Date:
30 September 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200209/lookinside/thumbnails/10.1055-s-2002-34418-1.jpg)
Abstract
Cucurbitacins 1 and 2 were isolated from the root of Trichosanthes kirilowii by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC50 = 0.18 μM and 6.7 μM, respectively), and the synthesis of melanin (IC50 = 0.16 μM and 7.5 μM, respectively) in B16/F10 melanoma cells.
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Prof. Won-Hong Woo
Professional Graduate School of Oriental Medicine
Wonkwang University
Iksan, Chonbuk 570-749, Korea
Email: whwoo@wonkwang.ac.kr
Fax: +82-63-850-5195