Subscribe to RSS
DOI: 10.1055/s-2002-34424
Tränennasenwegsstenose durch ein Zylindrom
Beschreibung einer ungewöhnlichen Tumormanifestation und LiteraturüberblickNasolacrimal Duct Obstruction Caused by a CylindromaReport of an Atypical Tumor Manifestation and Review of the LiteraturePublication History
Eingegangen: 17. Dezember 2001
Angenommen: 25. Juli 2002
Publication Date:
27 September 2002 (online)
Zusammenfassung
Hintergrund: Ziel der vorliegenden Arbeit ist es, Klinik, Diagnostik und Therapie sowie die histologischen Befunde eines Patienten mit einer durch ein Zylindrom verursachten postsakkalen Tränennasenwegsstenose darzustellen. Die bisher publizierten Reviewartikel sowie die aus der Medline-Datenbank recherchierten Einzelfallpublikationen von insgesamt 618 Tränensackneoplasien werden zusammengefasst. Kasuistik: Ein 79-jähriger Patient litt seit über 40 Jahren unter multiplen Zylindromen (Spiegler-Tumoren) des Kopfes. Er stellte sich mit seit sechs Monaten bestehender linksseitiger Epiphora vor und berichtete über einen Tumor wechselnder Größe im Bereich des Tränensackes. Während der Dakryozystorhinostomie zeigte sich eine Raumforderung, die den Übergang des Tränensackes in den Ductus nasolacrimalis verschloss. Nach kompletter Exzision ergab die histopathologische Beurteilung ein Zylindrom, das vermutlich ausgehend von der Dermis zu einem expansiven Wachstum in den Bereich des Tränensackes geführt hatte. Der Patient ist seit der Operation beschwerdefrei. Schlussfolgerung: In die Differenzialdiagnose der postsakkalen Tränennasenwegsstenose muss eine tumorbedingte Genese miteinbezogen werden. Nach unserem Kenntnisstand ist diese Kasuistik die erste Beschreibung einer postsakkalen Tränennasenwegsstenose, die durch ein Zylindrom verursacht wurde.
Abstract
Background: The purpose of this report is to describe the clinical characteristics, management and histological findings in a patient with obstruction of the nasolacrimal duct caused by a cylindroma. About 618 lacrimal sac tumours have been reported previously in reviews and case reports, which were reviewed after searching in medline database. Case report: A 79-year old man suffered from multiple cylindromas (Spiegler tumour) on his head for about 40 years. He presented with a 6 months' history of left-sided epiphora and a painless medial canthal mass of various size. A tumour which caused nasolacrimal duct obstruction was found during dacryocystorhinostomy. After complete excision histological examination revealed a cylindroma, which had shown expansive growth from dermis to the lacrimal sac area. The patient felt well; there was no longer any epiphora or dacryocystitis after the operation. Conclusion: Although very rare, lacrimal sac tumours must be considered in the differential diagnosis of nasolacrimal duct obstruction. To our knowledge this case represents the first report on an atypical manifestation on a Spiegler tumour in the lacrimal sac region.
Schlüsselwörter
Zylindrom - Spiegler-Tumor - Epiphora - Tränensacktumor - Tränenwegsstenose
Key words
Cylindroma - Spiegler tumour - epiphora - lacrimal sac tumour - nasolacrimal duct obstruction
Literatur
- 1 Scat Y, Liotet S, Carre F. Epidemiological study of 1705 malignant tumors of the eye and adnexa. J Fr Ophtalmol. 1996; 19, Nr. 2 83-88
-
2 Hornstein O P, Weidner F.
So genanntes dermales Cylindrom. In: Doerr W, Seifert G, Uehlinger E (Hrsg) Spezielle pathologische Anatomie. Bd. 7. Berlin, Heidelberg, New York; Springer 1979: 166-168 -
3 Murphy G F.
Cylindroma. In: Murphy GF Dermatopathology. Philadelphia, London, Toronto; W. B. Saunders 1995: 218-219 -
4 Requena L.
Cylindroma. In: Requena L, Kiryu H, Ackerman AB (eds) Neoplasms with apocrine differentiation. Philadelphia; Lippincott-Raven 1998: 429-433 - 5 Pizinger K, Michal M. Malignant cylindroma in brooke-spiegler syndrome. Dermatology. 2000; 201, Nr. 3 255-257
- 6 Martins C, Bartolo E. Brooke-Spiegler syndrome: treatment of cylindromas with CO2 Laser. Dermatol Surg. 2000; 9, Nr. 26 877-880
- 7 Fenske C, Banerjee P, Holden C, Carter N. Brooke-Spiegler syndrome locus assigned to 16q12 - q13. J Invest Dermatol. 2000; 5 1057-1058
- 8 Jones I S. Tumors of the lacrimal sac. Am J Ophthalmol. 1956; 42 561-566
- 9 Ni C, D'Amico D J, Fan C Q, Kuo P K. Tumors of the lacrimal sac: a clinicopathological analysis of 82 cases. Int Ophthalmol Clin. 1982; 22, Nr. 1 121-140
- 10 Stefanyszyn M A, Hidayat A A, Pe'er J J, Flanagan J C. Lacrimal sac tumors. Ophthal Plast Reconstr Surg. 1994; 10, Nr. 3 169-184
- 11 Flanagan J C, Mauriello J A. Management of lacrimal sac tumors. Adv Ophthalmic Plast Recontr Surg. 1984; 3 399-408
- 12 Hornblass A, Jakobiec F A, Bosniak S, Flanagan J. The diagnosis and management of epithelial tumors of the lacrimal sac. Ophthalmology. 1980; 87, Nr. 6 476-490
-
13 Duke-Elder S, MacFaul P A.
The ocular adnexa. Lacrimal passages. In: Duke-Elder S (ed) System of Ophthalmology. London; Kimpton 1974 Bd. XIII Pt. 2: 738-759 - 14 Radnot M, Gall J. Tumors of the lacrimal sac. Ophthalmologica. 1966; 151 Nr. 1 2-22
- 15 Ryan S J, Font R L. Primary epithelial neoplasms of the lacrimal sac. Am J Ophthalmol. 1973; 76, Nr. 1 73-88
- 16 Schenck N L, Ogura J H, Pratt L L. Cancer of the lacrimal sac. Presentation of five cases and review of the literature. Ann Otol Rhinol Laryngol. 1973; 82, Nr. 2 153-161
- 17 Francis I C, Kappagoda M B, Cole I E, Bank L, Dunn G D. Computed tomography of the lacrimal drainage system: retrospective study of 107 cases of dacryostenosis. Ophthal Plast Reconstr Surg. 1999; 15, Nr. 3 217-226
- 18 Weber A L, Rodriguez-DeVelasquez A, Lucarelli M J, Cheng H M. Normal anatomy and lesions of the lacrimal sac and duct: evaluated by dacryocystography, computed tomography, and MR imaging. Neuroimaging Clin N Am. 1996; 6, Nr. 1 199-217
- 19 Sagerman R H, Fariss A K, Chung C T, King G A, Yuo H S, Fries P D. Radiotherapy for nasolacrimal tract epithelial cancer. Int J Radiat Oncol Biol Phys. 1994; 29, Nr. 1 177-181
-
20 Busse H, Hollwich F.
Stenosen tumoröser Genese. In: Busse H, Hollwich F (Hrsg) Erkrankungen der ableitenden Tränenwege und ihre Behandlung. Stuttgart; Ferdinand Enke 1978: 142-146 - 21 Welham R A, Guthoff R. The Lester-Jones tube: a 15-year follow-up. Arch Ophthalmol. 1985; 223 106-108
- 22 Chang L, Trendell-Smith N, Olver J M. Surgical management of an unexpected lacrimal sac mass. Eye. 1999; 13 262-264
-
23 Duke-Elder S.
Diseases of the lacrimal passages. In: Duke-Elder S (ed) Textbook of Ophthalmology. Bd. 5. London; Kimpton 1952: 5279-5368 - 24 Pe'er J J, Stefanyszyn M, Hidayat A A. Nonepithelial tumors of the lacrimal sac. Am J Ophthalmol. 1994; 118, Nr. 5 650-658
- 25 Vala M. Primary carcinoma of the lacrimal sac region. Cesk Oftalmol. 1974; 30, Nr. 2 123-126
- 26 Wolpiuk M. Case of bilateral malignant lymphoma of the lacrimal sac. Klin Oczna. 1975; 45, Nr. 1 61-64
- 27 Flanagan J C, Stokes D P. Lacrimal sac tumors. Ophthalmology. 1978; 85, Nr. 12 1282-1287
- 28 Economides N G, Page R C. Metastatic melanoma of the lacrimal sac. Ann Plast Surg. 1985; 15, Nr. 3 244-246
- 29 Benger R S, Frueh B R. Lacrimal drainage obstruction from lacrimal sac infiltration by lymphocytic neoplasia. Am J Ophthalmol. 1986; 101, Nr. 2 242-245
- 30 Slonim C B, Older J J. Bilateral lymphocytic infiltrates causing dacryostenosis after bilateral successful dacryocystorhinostomies. Ophthal Plast Reconstr Surg. 1988; 4, Nr. 2 105-108
- 31 Stephenson J A, Mayland D M, Ingall G, Frank T W. Squamous cell carcinoma of the lacrimal sac. Otolaryngol Head Neck Surg. 1988; 99, Nr. 5 524-527
- 32 Gupta R K, Kumar S, Nath D, Singh S. Adenolymphoma of lacrimal sac. A case report. Indian J Cancer. 1990; 27, Nr. 2 116-118
- 33 Filipowicz-Banachowa A. Pathological changes found in the lacrimal sac during nasolacrimal duct surgery. Klin Oczna. 1991; 93, Nr. 2 - 3 89-90
- 34 Lee H M, Kang H J, Choi G, Chae S W, Kim C H, Hwang S J, Lee S H. Two cases of primary malignant melanoma of the lacrimal sac. Head Neck. 2001; 23, Nr. 9 809-813
- 35 Singh K, Mersol V F, Mastny V J, Naji A F. Adenoacanthoma of lacrimal sac. Ann Ophthalmol. 1977; 9, Nr. 8 1027-1029
- 36 Peretz W L, Ettinghausen S E, Gray G F. Oncocytic adenocarcinoma of the lacrimal sac. Arch Ophthalmol. 1978; 96, Nr. 2 303-304
- 37 Bambirra E A, Miranda D, Rayes A. Mucoepidermoid tumor of the lacrimal sac. Arch Ophthalmol. 1981; 99, Nr. 12 2149-2150
- 38 Blake J, Mullaney J, Gillan J. Lacrimal sac mucoepidermoid carcinoma. Br J Ophthalmol. 1986; 70, Nr. 9 681-685
- 39 Pe'er J, Hidaya A A, Ilsar M, Landau L, Stefanyszyn M A. Glandular tumors of the lacrimal sac. Their histopathologic patterns and possible origins. Ophthalmology. 1996; 103, Nr. 10 1601-1605
- 40 Jamieson I W. Haemangioma in lacrimal sac region, a case report. Trans Ophthalmol Soc N Z. 1975; 27 71
- 41 Lavergne G, Melon J, Delvigne-Van Lancker M, Gilson M. Inverted papilloma of the lacrimal sac. Bull Soc Belge Ophtalmol. 1973; 165, Nr. 0 323-334
- 42 Schindler R, Watson T A, Oliver G. Carcinoma of the lacrimal sac. Can J Ophthalmol. 1973; 8, Nr. 1 161-163
- 43 Khalil M K, Lorenzetti D W. Epidermoid carcinoma of the lacrimal sac: a clinicopathological case report. Can J Ophthalmol. 1980; 15, Nr. 1 40-43
- 44 Kohn R, Nofsinger K, Freedman S I. Rapid recurrence of papillary squamous cell carcinoma of the canaliculus. Am J Ophthalmol. 1981; 92, Nr. 3 363-367
- 45 Bonder D, Fischer M J, Levine M R. Squamous cell carcinoma of the lacrimal sac. Ophthalmology. 1983; 90, Nr. 9 1133-1135
- 46 Ni C, Wagoner M D, Wang W J, Albert D M, Fan C O, Robinson N. Mucoepidermoid carcinomas of the lacrimal sac. Arch Ophthalmol. 1983; 101, Nr. 10 1572-1574
- 47 Kincaid M C, Meis J M, Lee M W. Adenoid cystic carcinoma of the lacrimal sac. Ophthalmology. 1989; 96, Nr. 11 1655-1658
- 48 Parnell J R, Mamalis N, Davis R K, Flaharty P M, Anderson R L. Primary adenoid cystic carcinoma of the lacrimal sac: report of a case. Ophthal Plast Reconstr Surg. 1994; 10, Nr. 2 124-129
- 49 Poncet P, Beaumont A, Coupez D, Schlienger P, Bataini J P, Haye C. Epithelioma of the lacrimal sac. Review of the literature and analysis of 8 cases. Ann Otolaryngol Chir Cervicofac. 1983; 100, Nr. 6 397-402
- 50 Das A, Chowdhury S, Mitra J N, Sengupta P, Roy I S. Fibrous histiocytoma of the lacrimal sac. Indian J Ophthalmol. 1983; 31, Nr. 2 S. 87-88
- 51 Lloyd W C, Leone C R. Malignant melanoma of the lacrimal sac. Arch Ophthalmol. 1984; 102, Nr. 1 104-107
- 52 Lamping K A, Albert D M, Ni C, Fournier G. Oxyphil cell adenomas. Three case reports. Arch Ophthalmol. 1984; 102, Nr. 2 263-265
- 53 Arne J L, Salvaing P, Chevalier J P, Bourdiol A M. Neurofibroma of the lacrimal sac. Apropos of a case. Bull Soc Ophtalmol Fr. 1984; 84, Nr. 5 665-669
- 54 George J L, Heymann V, Vignaud J M, Barthelme A. Epidermoid carcinoma of the lacrimal sac after acute post-traumatic dacryocystitis. J Fr Ophtalmol. 1987; 10, Nr. 8 - 9 515-517
- 55 Khan J A, Sutula F C, Pilch B Z, Joseph M P. Mucoepidermoid carcinoma involving the lacrimal sac. Ophthal Plast Reconstr Surg. 1988; 4, Nr. 3 153-157
- 56 Jordan D R, Nerad J A. Diffuse large-cell lymphoma of the nasolacrimal sac. Can J Ophthalmol. 1988; 23, Nr. 1 34-37
- 57 Carnevali L, Trimarchi F, Rosso R, Stringa M. Haemangiopericytoma of the lacrimal sac: a case report. Br J Ophthalmol. 1988; 72, Nr. 10 782-785
- 58 Khan J A, Grove A S, Joseph M P, Goodman M. Sebaceous carcinoma. Diuretic use, lacrimal system spread, and surgical margins. Ophthal Plast Reconstr Surg. 1989; 5, Nr. 4 227-234
- 59 Stefanescu-Dima A, Petria I, Craitoiu S. Carcinoma of the lacrimal sac. Rev Chir Oncol Radiol ORL Oftalmol Stomatol Ser Oftalmol. 1989; 33, Nr. 3 231-234
- 60 Glaros D, Karesh J W, Rodrigues M M, Hirsch D R, Zimmerman L E. Primary malignant melanoma of the lacrimal sac. Arch Ophthalmol. 1989; 107, Nr. 8 1244-1245
- 61 Mullaney J. Peculiar ophthalmic proliferations. Eye. 1990; 4, Nr. Pt 1 79-88
- 62 Ferry A P, Kaltreider S A. Cavernous hemangioma of the lacrimal sac. Am J Ophthalmol. 1990; 110, Nr. 3 316-318
- 63 Roth S I, August C Z, Lissner G S, O'Grady R B. Hemangiopericytoma of the lacrimal sac. Ophthalmology. 1991; 98, Nr. 6 925-927
- 64 Filipowicz-Banachowa A, Sidorowicz E. Neurofibroma of the lacrimal sac. Klin Oczna. 1991; 93, Nr. 9 271-272
- 65 Levin P S, Dutton J J. A 20-year series of orbital exenteration. Am J Ophthalmol. 1991; 112, Nr. 5 496-501
- 66 Lim K H, Kim Y D, Kim Y I. Hemangiopericytoma of the lacrimal sac. Korean J Ophthalmol. 1991; 5, Nr. 2 88-91
- 67 Rubin P A, Shore J W, Jakobiec F A, To K. Hemangiopericytoma of the lacrimal sac. Ophthalmic Surg. 1992; 23, Nr. 8 562-563
- 68 Eide N, Refsum S B, Bakke S. Primary malignant melanoma of the lacrimal sac. Acta Ophthalmol (Copenh). 1993; 71, Nr. 2 273-276
- 69 Karesh J W, Perman K I, Rodrigues M M. Dacryocystitis associated with malignant lymphoma of the lacrimal sac. Ophthalmology. 1993; 100 Nr. 5 669-673
- 70 Fliss D M, Freeman J L, Hurwitz J J, Heathcote J G. Mucoepidermoid carcinoma of the lacrimal sac: a report of two cases, with observations on the histogenesis. Can J Ophthalmol. 1993; 28, Nr. 5 228-235
- 71 Fishman J R, Gladstone G J, Jackson I T. Squamous cell carcinoma of the lacrimal sac. Plast Reconstr Surg. 1993; 92, Nr. 7 1375-1379
- 72 Anderson K K, Lessner A M, Hood I, Mendenhall W, Stringer S, Warren R. Invasive transitional cell carcinoma of the lacrimal sac arising in an inverted papilloma. Arch Ophthalmol. 1994; 112, Nr. 3 306-307
- 73 Kheterpal S, Chan S Y, Batch A, Kirkby G R. Previously undiagnosed lymphoma presenting as recurrent dacryocystitis. Arch Ophthalmol. 1994; 112, Nr. 4 519-520
- 74 Domanski H, Ljungberg O, Andersson L O, Schele B. Oxyphil cell adenoma (oncocytoma) of the lacrimal sac. Review of the literature. Acta Ophthalmol (Copenh). 1994; 72, Nr. 3 393-396
- 75 Rahangdale S R, Castillo M, Shockley W. MR in squamous cell carcinoma of the lacrimal sac. AJNR Am J Neuroradiol. 1995; 16, Nr. 6 1262-1264
- 76 Perlman J I, Specht C S, McLean I W, Wolfe S A. Oncocytic adenocarcinoma of the lacrimal sac: report of a case with paranasal sinus and orbital extension. Ophthalmic Surg. 1995; 26, Nr. 4 377-379
- 77 Tomic S, Warner T F, Brandenburg J H. Malignant oncocytoma of the lacrimal sac: ultrastructure and immunocytochemistry. Ear Nose Throat J. 1995; 74, Nr. 10 717-720
- 78 Leung S Y, Chung L P, Ho C M, Yuen S T, Wong M P, Kwong W K. An Epstein-Barr virus positive undifferentiated carcinoma in the lacrimal sac. Histopathology. 1996; 28, Nr. 1 71-75
- 79 Owens R M, Wax M K, Kostik D, Linberg J V, Hogg J. Malignant melanoma of the lacrimal sac. Otolaryngol Head Neck Surg. 1995; 113, Nr. 5 634-640
- 80 Levine M R, Dinar Y, Davies R. Malignant melanoma of the lacrimal sac. Ophthalmic Surg Lasers. 1996; 27, Nr. 4 318-320
- 81 Karim M M, Inoue M, Minato K, Yamamoto M, Kanomata N, Ohbayashi C, Ito H. Eccrine adenocarcinoma of the lacrimal sac region. Ophthalmologica. 1997; 211, Nr. 1 44-48
- 82 Choi G, Lee U, Won N H. Fibrous histiocytoma of the lacrimal sac. Head Neck. 1997; 19, Nr. 1 72-75
- 83 Malik T Y, Sanders R, Young J D, Brennand E, Evans A T. Malignant melanoma of the lacrimal sac. Eye. 1997; 11, Nr. Pt 6 935-937
- 84 Brosig J, Warzok R, Clemens S. Primary high malignancy B-cell lymphoma of the lacrimal sac. Klin Monatsbl Augenheilkd. 1998; 212, Nr. 6 473-475
- 85 Chen L J, Liao S L, Kao S C, Wu C T, Hou P K, Chen M S. Oncocytic adenomatous hyperplasia of the lacrimal sac: a case report and review of the literature. Ophthal Plast Reconstr Surg. 1998; 14, Nr. 6 436-440
- 86 Charles N C, Palu R N, Jagirdar J S. Hemangiopericytoma of the lacrimal sac. Arch Ophthalmol. 1998; 116, Nr. 12 677-680
- 87 Spielmann A C, Debelle L, Lederlin P, Antunes L, George J L. Massive bone destruction: an atypical sign of orbital lymphoma. J Fr Ophtalmol. 1998; 21, Nr. 10 769-772
- 88 El-Hakim H, Nunez D A. Non-Hodgkin's lymphoma of the lacrimal sac and concomitant pansinusitis. J Laryngol Otol. 1998; 112, Nr. 10 969-970
- 89 Luchtenberg M, Emmerich K H. Hydrops of the lacrimal sac with epiphora of the right eye. Transitional cell carcinoma of the lacrimal sac. Ophthalmologe. 1999; 96, Nr. 4 274-275
- 90 Woo K I, Suh Y L, Kim Y D. Solitary fibrous tumor of the lacrimal sac. Ophthal Plast Reconstr Surg. 1999; 15, Nr. 6 450-453
- 91 Fishman G, Ophir D. Malignant melanoma of the lacrimal sac: a case study. Am J Otolaryngol. 1999; 20, Nr. 5 336-339
- 92 Hung S L, Ma L. Recurrent lacrimal sac papilloma: case report. Changgeng Yi Xue Za Zhi. 2000; 23, Nr. 2 113-117
- 93 Mori T, Tokuhira M, Mori S, Sato N, Miura I, Adachi A, Kuroda H, Tamaru J, Itoyama S, Suzuki H, Abe T, Takeuchi T. Primary natural killer cell lymphoma of the lacrimal sac. Ann Hematol. 2001; 80, Nr. 10 607-610
- 94 Nakamura K, Uehara S, Omagari J, Kunitake N, Kimura M, Makino Y, Ishigami K, Masuda K. Primary non-Hodgkin's lymphoma of the lacrimal sac: a case report and a review of the literature. Cancer. 1997; 80, Nr. 11 2151-2155
- 95 Li J, Wang W. A case report of primary lacrimal sac adenocarcinoma. Yan Ke Xue Bao. 1993; 9, Nr. 4 224
- 96 Kuwabara H, Takeda J. Malignant melanoma of the lacrimal sac with surrounding melanosis. Arch Pathol Lab Med. 1997; 121, Nr. 5 517-519
- 97 Older J J, Sims L M. Canaliculorhinostomy following dacryocystectomy for removal of a benign fibrous histiocytoma of the lacrimal sac. Ophthalmic Surg. 1993; 24, Nr. 11 753-754
- 98 Marback R L, Kincaid M C, Green W R, Iliff W J. Fibrous histiocytoma of the lacrimal sac. Am J Ophthalmol. 1982; 93, Nr. 4 511-517
- 99 Yoshida T, Nagata K, Mihashi S. Squamous cell carcinoma presumebly originating from the lacrimal sac - report of a case. Kurume Med J. 1982; 29, Suppl 57-59
- 100 Sen D K, Mohan H. Fibroma of the lacrimal sac. J Pediatr Ophthalmol Strabismus. 1980; 17, Nr. 6 410-411
- 101 Schreinzer W, Breitfellner G. Primary malignant melanoma of the lacrimal sac. Klin Monatsbl Augenheilkd. 1980; 176, Nr. 2 262-265
- 102 Nover A. Malignant non-Hodgkin-lymphomas on lid, orbita and lacrimal sac (author's transl). Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979; 210, Nr. 3 211-218
- 103 Johnson G D. Carcinoma of the lacrimal sac. Trans Pa Acad Ophthalmol Otolaryngol. 1979; 32, Nr. 1 28-31
- 104 Yamade S, Kitagawa A. Malignant melanoma of the lacrimal sac. Ophthalmologica. 1978; 177, Nr. 1 30-33
- 105 Cole S H, Ferry A P. Fibrous histiocytoma (fibrous xanthoma) of the lacrimal sac. Arch Ophthalmol. 1978; 96, Nr. 9 1647-1649
- 106 Maciejasz A, Petrysowa F. Melanoblastoma of the lacrimal sac. Klin Oczna. 1976; 46, Nr. 1 71-74
- 107 Sabet S J, Tarbet K J, Lemke B N, Smith M E, Albert D M. Granular cell tumor of the lacrimal sac and nasolacrimal duct: no invasive behavior with incomplete resection. Ophthalmology. 2000; 107, Nr. 11 1992-1994
- 108 Ardenghy M, Hochberg J, de Sordi G. Granuloma of the lacrimal sac. W V Med J. 1996; 92, Nr. 2 92-93
Dr. med. M. Schittkowski
Universitätsaugenklinik
Doberaner Straße 140
18057 Rostock
Email: michael.schittkowski@med.uni-rostock.de