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Am J Perinatol 2002; 19(6): 317-322
DOI: 10.1055/s-2002-34463
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Serial Protein S-100 Serum Levels in Preterm Babies with Perinatal Asphyxia and Periventricular White Matter Lesions

G. Distefano1 , R. Curreri1 , P. Betta1 , M. T. Isaja1 , M. G. Romeo1 , M. Amato2
  • 1Department of Pediatrics, University of Catania, Italy
  • 2Faculty of Medicine, University of Berne, Switzerland
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Publication Date:
01 October 2002 (online)

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ABSTRACT

In the last years new diagnostic technologies were developed to assess brain development and to identify early brain injury. Some of them are very attractive methods but invasive, expensive, and time-consuming. The availability of clinically useful serum markers of risk for perinatal brain damage will easily permit the development of rational strategies for prevention of cerebral insults in neonates and more accurate prognostic counseling. In this study, protein S-100 (PS-100), a cytosolic constituent of neuroglial cells, was measured serially, during the neonatal period, in a group of preterm infants suffering perinatal asphyxia. Protein S-100 was measured at 1, 7, and 21 days of life by radioimmunoassay. Cerebral ultrasound confirmed cerebral white matter insult. The results of this study show significantly higher protein S-100 serum levels in asphyxiated preterm babies with periventricular white matter lesions, with a peak at 24 hours of life (5.7 ± 2.9 μg/L) compared with healthy preterm babies (0.6 ± 0.3 μg/L) (p <0.05) and progressively lower values at seven (3.3 ± 2.4 μg/L) and 21 days (2.2 ± 1.3 μ/L) of life (p <0.05). These data suggest that elevated protein S-100 serum levels can be considered an indicator of regional brain damage in preterm infants, allowing noninvasive, superior scrutiny of perinatal asphyxia and potential early preventive strategies.

KEYWORDS

Protein S-100 - perinatal asphyxia - white matter lesion - preterm infant

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