Abstract
The utility of tetrathiomolybdate in a variety of organic transformations
is presented in this account. The sulfur transfer ability of tetrathiomolybdate
is exploited in the synthesis of organic disulfides under mild reaction
conditions. The induced internal redox reactions associated with
tetrathiomolybdate have been thoroughly exploited in developing
various methodologies, which include the reduction of organic azides,
synthesis of diselenides, cyclic imines, thioamides, and thiolactams.
In addition, novel deprotection strategies using tetrathiomolybdate
have been developed to cleave the propargyl and propargyloxy carbonyl
(POC) protecting groups. Tetrathiomolybdate mediated tandem sulfur
transfer-reduction-Michael reactions have been applied to the synthesis
of sulfur containing bicyclic systems. Furthermore, the reactions
in the solid state and the reactions in water medium assisted by
tetrathiomolybdate have greatly simplified the synthesis of organic
disulfides.
Key words
molybdenum - sulfur - tetrathiomolybdate - disulfides - protecting groups - tandem reactions
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