Int J Sports Med 2002; 23(7): 495-499
DOI: 10.1055/s-2002-35070
Physiology & Biochemistry

© Georg Thieme Verlag Stuttgart · New York

Markers of Coagulation, Fibrinolysis and Angiogenesis After Strenuous Short-Term Exercise (Wingate-Test) in Male Subjects of Varying Fitness Levels

H.-C.  Gunga1 , K.  Kirsch1 , R.  Beneke 2 , D.  Böning2 , W.  Hopfenmüller 3 , R.  Leithäuser 4 , M.  Hütler 2 , L.  Röcker 1
  • 1 Department of Physiology, Center of Space Medicine, Free University of Berlin, Clinical Center Benjamin Franklin, Berlin, Germany
  • 2 Department of Sports Medicine, Free University of Berlin, Clinical Center Benjamin Franklin, Berlin, Germany
  • 3 Department of Biometrics and Clinical Epidemiology, Free University of Berlin, Clinical Center Benjamin Franklin, Berlin, Germany
  • 4 Laboratory 28, Berlin, Germany
Further Information

Publication History

Accepted after revision: April 6, 2002

Publication Date:
28 October 2002 (online)

Abstract

It was the aim of the study to analyse the haemostatic system during a high standardized intensive short-term (30 s) exercise (anaerobic Wingate test). Blood samples were taken from 15 male subjects before (t0), and within 2 (t1), 9 (t2) and 30 min (t3) after the test. We found that the partial thromboplastin time was markedly shortened, whereas the prothrombin time increased slightly from t0 to t1 (p < 0.002) and remained elevated (t3, p < 0.046). Factor VIII increased from t0 to t1 (p < 0.001) and remained elevated as well (t3, p < 0.001). Fibrin monomers were approximately 15 times higher immediately post-exercise (t1, p < 0.001) and continued to be elevated (t3, p < 0.004). The tissue plasminogen activator increased by 4 times after exercise (t1, p < 0.001) and remained elevated (t3, p < 0.002). The d-dimers increased from t0 to t1 (p < 0.001) as well and remained elevated (t3, p < 0.005). Thrombopoietin concentrations were unchanged, whereas the vascular endothelial growth factor increased immediately post-exercise (t0 to t1, p < 0.011 resp. at t2 p < 0.019) and returned to the control level at t3 (p < 0.878). In conclusion, it was found that prothrombotic markers and, even more pronounced, those of the fibrinolytic system were increased. The study provides evidence that due to intensive short-term exercise the balance of the haemostatic system is shifted to a higher equilibrium. Theoretically, the data show that in the case of a subject with risk factors such as impaired fibrinolysis, unfavourable conditions cannot be excluded.

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H.-C. Gunga, M. D., Ph. D.

Department of Physiology · Free University of Berlin

Arnimallee 22 · 14195 Berlin · Germany ·

Phone: + 49 (30) 8445-1656, -1655

Fax: + 49 (30) 8445-1658

Email: Gunga@zedat.fu-berlin.de