Subscribe to RSS
DOI: 10.1055/s-2002-35211
Angioendotheliomatose
Eine LiteraturübersichtAngioendotheliomatosisA Literature OverviewPublication History
Publication Date:
04 November 2002 (online)
Zusammenfassung
Wir berichten über eine 57-jährige Patientin mit multiplen livid-roten Hautinfiltraten im Bereich beider Ohrhelices. Die Diagnose einer reaktiven Angioendotheliomatose wurde histologisch, immunhistologisch und elektronenmikroskopisch anhand proliferierender Endothelzellen mit intravasalen Fibrinthromben gestellt. Verschiedenste Therapieansätze konnten die Erkrankung bei nicht nachweisbarer Grund- bzw. Begleiterkrankung nur mäßig beeinflussen. Wir geben eine Literaturübersicht zur benignen und malignen Form der Angioendotheliomatose.
Abstract
We report about a 57-year-old female patient with multiple livid red skin infiltrations in the area of both ear helices. A reactive angioendotheliomatosis was diagnosed histologically, immunhistologically and by means of electron microscopy showing proliferating endothelial cells with intravasal fibrin thrombus. Different therapeutic concepts could not influence the course of the disease distinctly as the primary or accompanying illness could not be found. We give a review of literature regarding benign and malignant forms of angioendotheliomatosis.
Literatur
- 1 Chakravarty K, Goyal M, Scott D GI, McCann B G. Malignant „angioendotheliomatosis” - (intravascular lymphomatosis) an unusual cutaneous lymphoma in rheumatoid arthritis. Br J Rheumatol. 1993; 32 932-934
- 2 Chang A, Zic J A, Boyd A S. Intravascular large cell lymphoma: a patient with asymptomatic purpuric patches and a chronic clinical course. J Am Acad Dermatol. 1998; 39 318-321
- 3 Chen M, Qiu B, Kong J, Chen J. Angiotropic T cell lymphoma. Chin Med J (Engl). 1998; 111 762-764
- 4 Creamer D, Black M M, Calonje E. Reactive angioendotheliomatosis in association with the antiphospholipid syndrome. J Am Acad Dermatol. 2000; 42 903-906
- 5 Crocker J, Hall P A, Macartney J C, Stansfeld A G. A comparative study of nucleolar organizer regions (AgNORs), Ki 67 staining and DNA flow cytometry in non-Hodgkin's lymphomas. J Pathol. 1988; 154 37A
- 6 Eisert J. Skin manifestations of subacute bacterial endocarditis: case report of subacute bacterial endocarditis mimicking Tappeiner's angioendotheliomatosis. Cutis. 1980; 25 394-400
- 7 Ferry J A, Harris N L, Picker L J, Weinberg D S, Rosales R K, Tapia J, Richardson E P Jr. Intravascular lymphomatosis (malignant angioendotheliomatosis). A B-cell neoplasm expressing surface homing receptors. Mod Pathol. 1988; 1 444-452
- 8 Gottron H A, Nikolowski W. Extrarenale Löhlein-Herdnephritis der Haut bei Endocarditis. Arch Klin Exp Dermatol. 1958; 207 156-176
- 9 Khalidi H S, Brynes R K, Browne P, Koo C H, Battifora H, Medeiros L J. Intravascular large B-cell lymphoma: the CD5 antigen is expressed by a subset of cases. Mod Pathol. 1998; 11 983-988
- 10 Kim S, Elenitsas R, James W D. Diffuse dermal angiomatosis: a variant of reactive angioendotheliomatosis associated with peripheral vascular atherosclerosis. Arch Dermatol. 2002; 138(4) 456-458
- 11 Kimyai-Asadi A, Nousari H C, Ketabchi N, Henneberry J M, Costarangos C. Diffuse dermal angiomatosis: a variant of reactive angioendotheliomatosis associated with atherosclerosis. J Am Acad Dermatol. 1999; 40 257-259
- 12 Knobel B, Sommer I, Petchenko P, Lev D, Okon E. Malignant humoral hypercalcemia associated with angiotropic large B cell lymphoma. Harefuah. 2001; 140 204-206, 287
- 13 Kolde G. Angioendotheliomatosis proliferans systematisata. Hautarzt. 1991; 42 589-592
- 14 Krell J M, Sánchez R L, Solomon A R. Diffuse dermal angiomatosis: a variant of reactive cutaneous angioendotheliomatosis. J Cutan Pathol. 1994; 21 363-370
- 15 Kutzner H, Englert W, Hellenbroich D, Embacher G, Kutzner U, Schröder U. Angioendotheliomatosis proliferans systemisata: eine kutane Manifestation maligner Lymphome. Hautarzt. 1991; 42 384-390
- 16 Lazova R, Slater C, Scott G. Reactive angioendotheliomatosis. Am J Dermatopathol. 1996; 18 63-69
- 17 LeBoit P E, Solomon A R, Santa Cruz , Wick M R. Angiomatosis with luminal cryoprotein disposition. J Am Acad Dermatol. 1992; 27 969-973
- 18 Lim H W, Anderson H M. Angioendotheliomatosis associated with histiocytic lymphoma: response to systematic chemotherapy. J Am Acad Dermatol. 1985; 13 903-908
- 19 López-Gil F, Roura M, Umbert I, Umbert P. Malignant proliferative angioendotheliomatosis or angiotropic lymphoma associated with a soft-tissue lymphoma. J Am Acad Dermatol. 1992; 26 101-104
- 20 Martin S, Pitcher D, Tschen J, Wolf J E. Reactive angioendotheliomatosis. J Am Acad Dermatol. 1980; 2 117-123
- 21 O'Grady J T, Shahidullah H, Doherty V R, Al-Nafussi A. Intravascular histiocytosis. Histopathology. 1994; 24 265-268
- 22 Pasyk K, Depowski M. Proliferation systematized angioendotheliomatosis of a 5 month-old infant. Arch Dermatol. 1978; 114 1512-1515
- 23 Pfleger L, Tappeiner J. Zur Kenntnis der systemisierten Endotheliomatose der kutanen Blutgefäße (Retikuloendotheliose?). Hautarzt. 1959; 10 359-363
- 24 Porras-Luque J I, Fernández-Herrera J, Daudén E, Fraga J, Fernández-Villalta M J, García-Díez A. Cutaneous necrosis by cold agglutinins associated with glomeruloid reactive angioendotheliomatosis. Br J Dermatol. 1998; 139 1068-1072
- 25 Quinn T R, Alora M BT, Momtaz K T, Taylor C R. Reactive angioendotheliomatosis with underlying hepatopathy and hypertensive portal gastropathy. Int J Dermatol. 1998; 37 378-385
- 26 Requena L, Farina M C, Renedo G, Alvarez A, Yus E S, Sangueza O P. Intravascular and diffuse dermal reactive angioendotheliomatosis secondary to iatrogenic arteriovenous fistulas. J Cutan Pathol. 1999; 26 159-164
- 27 Rieger E, Soyer H P, Leboit P E, Metze D, Slovak R, Kerl H. Reactive angioendotheliomatosis or intravascular histiocytosis? An immunhistochemical and ultrastructural study in two cases of intravascular histiocytic cell proliferation. Br J Dermatol. 1999; 140 497-504
- 28 Ruiter M, Mandema E. New cutaneous syndrome in subacute bacterial endocarditis. Arch Intern Med. 1964; 113 283-290
- 29 Salama S, Jenkis P. Angiomatosis with intravascular immunoglobulin deposits: a new cutaneous marker for chronic lymphocytic leukemia. A case report with immunohistochemical correlation. Am J Dermatopathol. 1999; 21 73
- 30 Schmidt K, Hartig C, Stadler R. Reaktive Angioendotheliomatose bei chronisch lymphatischer Leukämie. Hautarzt. 1996; 47 550-555
- 31 Scott P WB, Silvers D N, Helwig E B. Proliferating angioendotheliomatosis. Arch Pathol. 1975; 99 323-326
- 32 Tomasini C, Soro E, Pippione M. Angioendotheliomatosis in a woman with rheumatoid arthritis. J Am Acad Dermatol. 2000; 22 334-338
- 33 Umbert P, Lopez F, Umbert I. Malignant proliferative angioendotheliomatosis or T-angio-lymphoma associated with a soft-tissue T-lymphoma. J Cutan Pathol. 1998; 16 329
- 34 Waring W S, Wharton S B, Grant R, McIntyre M. Angiotropic large B-cell lymphoma with clinical features resembling subacute combined degeneration of the cord. Clin Neurol Neurosurg. 1999; 101 275-279
- 35 Wick M R, Rocamora A. Reactive and malignant “angioendotheliomatosis”: a discriminant clinicopathological study. J Cutan Pathol. 1988; 15 260-271
Dr. med. Katja Wallenfang
Hautklinik Klinikum Minden
Portastraße 7 - 9 · 32423 Minden
Email: hautklinik@klinikum-minden.de