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Synthesis 2002(17): 2601-2608
DOI: 10.1055/s-2002-35618
DOI: 10.1055/s-2002-35618
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart · New York
Indium-Mediated Reformatsky-Type Reaction of β-Aminovinyl Chlorodifluoromethyl Ketones with Heteroaryl Aldehydes
Further Information
Received
23 October 2002
Publication Date:
20 November 2002 (online)
Publication History
Publication Date:
20 November 2002 (online)
Abstract
Indium can efficiently mediate the Reformatsky-type reaction between some β-aminovinyl chlorodifluoromethyl ketones and a series of heteroaryl aldehydes, to afford the corresponding difluoromethylene compounds in good to high yields.
Key words
indium - Reformatsky - fluorine - β-aminovinyl ketones - nucleophilic additions
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