Abstract
New and recent work by the author and colleagues will be presented.
Six methods for functionalizing halogenated ethers will be presented:
(1) a new regent for halogen-exchange fluorination of chloromethyl
ethers, (2) a selective photochemical or thermal reduction of poly-chlorinated
substrates, (3) new organic sources of fluoride for antimony-pentachloride-catalyzed
halogen-exchange fluorination, (4) a chemoselective methanolysis
reaction of the trifluoromethyl group, (5) a stereoselective decarboxylation reaction,
and (6) the use of bromine trifluoride for fluorination with inversion
of configuration. The reactions are applied to the synthesis of
individual enantiomers of fluoroether anesthetics.
Key words
fluorine - halogenation - drugs - halogenated
ethers - halogen-exchange fluorination
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