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DOI: 10.1055/s-2002-35654
© Georg Thieme Verlag Stuttgart · New York
Cycloartane and Oleanane Saponins from Egyptian Astragalus spp. as Modulators of Lymphocyte Proliferation
Publikationsverlauf
Received: March 18, 2002
Accepted: May 25, 2002
Publikationsdatum:
26. November 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200211/lookinside/thumbnails/10.1055-s-2002-35654-1.jpg)
Abstract
From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3-O-[β-D-(2′,3′-diacetyl, 4′-trans-2-butenoyl)-xylopyranosyl], 6-O-β-D-xylopyranoside (kahiricoside I). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
Key words
Astragalus spp. - Leguminosae - cycloartane-type saponins - oleanane-type saponins - lymphocytes proliferation modulators
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Dr. Luisella Verotta
Dipartimento di Chimica Organica e Industriale
Università degli Studi di Milano
via Venezian 21, 20133 Milano
Italy
Fax: +39 02 5031 4106.
eMail: luisella.verotta@unimi.it