Planta Med 2002; 68(11): 1052-1054
DOI: 10.1055/s-2002-35670
Letter
© Georg Thieme Verlag Stuttgart · New York

5-Hydroxyramulosin, a New Natural Product Produced by Phoma tropica, a Marine-Derived Fungus Isolated from the Alga Fucus spiralis

Claudia Osterhage1 , Gabriele M. König1 , Peter G. Jones2 , Anthony D. Wright1
  • 1Current address: Institute for Pharmaceutical Biology, University of Bonn, Nußallee 6, Bonn, Germany
  • 2Institute for Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany
Further Information

Publication History

Received: February 13, 2002

Accepted: June 29, 2002

Publication Date:
26 November 2002 (online)

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Abstract

The fungus Phoma tropica was isolated from the inner tissue of the marine brown alga Fucus spiralis. After large-scale cultivation the fungus was investigated for its secondary metabolite content and found to contain the new natural product 5-hydroxyramulosin (1) together with 7-methoxycoumarin. Both structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR, and in the case of 1, a single crystal X-ray diffraction analysis.