Therapie des komplizierten Ulkus

Die Blutung, Perforation, Penetration und Obstruktion durch benigne entzündliche oder postentzündliche Stenosen stellen die wesentlichen Ulkuskomplikationen dar.

Literatur

• 1 Peura D A, Lanza F L, Gostout C J. et al . The American College of Gastro­enterology Bleeding Registry: preliminary findings.  Am J Gastro­enterol. 1997;  92 (6) 924-928
• 2 Rockall T A, Logan R F, Devlin H B. et al . Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage.  BMJ. 1995;  311 (6999) 222-226
• 3 Vreeburg E M, Snel P, de Bruijne J W. et al . Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis, and clinical outcome.  Am J Gastroenterol. 1997;  92 (2) 236-243
• 4 Czernichow P, Hochain P, Nousbaum J B. et al . Epidemiology and course of acute upper gastro-intestinal haemorrhage in four French geographical areas.  Eur J Gastroenterol Hepatol. 2000;  12 (2) 175-181
• 5 Laine L. Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient.  Gastroenterology. 2001;  120 (3) 594-606
• 6 de Abajo F J, Garcia R odriguez LA. Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and ­enteric-coated formulations.  BMC Clin Pharmacol. 2001;  1 (1) 1
• 7 Selby N M, Kubba A K, Hawkey C J. Acid suppression in peptic ulcer ­haemorrhage: a ‘meta-analysis’.  Aliment Pharmacol Ther. 2000;  14 (9) 1119-1126
• 8 Lau J Y, Sung J J, Lee K K. et al . Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers.  N Engl J Med. 2000;  343 (5) 310-316
• 9 Vreeburg E M, Levi M, Rauws E A. et al . Enhanced mucosal fibrinolytic activity in gastroduodenal ulcer haemorrhage and the beneficial effect of acid suppression.  Aliment Pharmacol Ther. 2001;  15 (5) 639-646
• 10 Ell C, Hagenmueller F, Schmitt W. et al . Mulitcenter prespective study of the current status of treatment for bleeding ulcer in Germany.  Dtsch Med Wochenschr. 1995;  120 (1-2) 3-9
• 11 Chung I K, Kim E J, Lee M S, Kim H S. et al . Bleeding Dieulafoy’s lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods.  Gastrointest Endosc. 2000;  52 (6) 721-724
• 12 Jensen D M, Kovacs T O, Jutabha R. et al . Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots.  Gastroenterology. 2002;  123 (2) 407-413
• 13 Kohler B, Maier M, Benz C. et al . Acute ulcer bleeding. A prospective randomized trial to compare Doppler and Forrest classifications in endoscopic diagnosis and therapy.  Dig Dis Sci. 1997;  42 (7) 1370-1374
• 14 Cocks J R. Perforated peptic ulcer-the changing scene.  Dig Dis. 1992;  10 (1) 10-16
• 15 Stabile B E. Surgical treatment of peptic ulceration.  Curr Opin Gen Surg. 1993;  206-215
• 16 Hermansson M, von Stael H olstein C, Zilling T. Peptic ulcer perforation before and after the introduction of H2-receptor blockers and proton pump inhibitors.  Scand J Gastroenterol. 1997;  32 (6) 523-529
• 17 Sanchez-Bueno F, Marin P, Rios A. et al . Has the incidence of perforated peptic ulcer decreased over the last decade?.  Dig Surg. 2001;  18 (6) 444-447; discussion 447-448
• 18 Paimela H, Joutsi T, Kiviluoto T. et al . Recent trends in mortality from peptic ulcer disease in Finland.  Dig Dis Sci. 1995;  40 (3) 631-635
• 19 Svanes C, Soreide J A, Skarstein A. et al . Smoking and ulcer perforation.  Gut. 1997;  41 (2) 177-180
• 20 Doll R, Peto R, Wheatley K. et al . Mortality in relation to smoking: 40 years’ observations on male British doctors.  BMJ. 1994 Oct;  309 (6959) 901-911
• 21 Evans J M, McMahon A D, McGilchrist M M. et al . Topical non-steroidal anti-inflammatory drugs and admission to hospital for upper gastrointestinal bleeding and perforation: a record linkage case-control study.  BMJ. 1995;  311 (6996) 22-26
• 22 Garcia R odriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs.  Lancet. 1994;  343 (8900) 769-772
• 23 Henry D, Dobson A, Turner C. Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs.  Gastroenterology. 1993;  105 (4) 1078-1088
• 24 Svanes C, Ovrebo K, Soreide O. Ulcer bleeding and perforation: non-steroidal anti-inflammatory drugs or Helicobacter pylori.  Scand J Gastroenterol Suppl. 1996;  220 128-131
• 25 Sharma A K, Mittal S, Malvi S K. Association of Helicobacter pylori with peptic perforation in Chattisgarh region of India.  Trop Gastroenterol. 2000;  21 (1) 42-43
• 26 Ng E K, Lam Y H, Sung J J. et al . Eradication of Helicobacter pylori prevents recurrence of ulcer after simple closure of duodenal ulcer perforation: randomized controlled trial.  Ann Surg. 2000;  231 (2) 153-158
• 27 Bergamaschi R, Marvik R, Johnsen G. et al . Open vs laparoscopic repair of perforated peptic ulcer.  Surg Endosc. 1999;  13 (7) 679-682
• 28 Siu W T, Leong H T, Law B K. et al . Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial.  Ann Surg. 2002;  235 (3) 313-319
• 29 Kirstensen E S. Conservative treatment of 155 cases of perforated peptic ulcer.  Acta Chir Scand. 1980;  146 189
• 30 Crofts T J, Park K G, Steele R J. et al . A randomized trial of nonoperative treatment for perforated peptic ulcer.  N Engl J Med. 1989;  320 (15) 970-973
• 31 Becker H D. Chirurgische Therapie der Ulkusperforation. Chirurgische Gastroenterologie, Bd. 2 Berlin; Springer 1990: 834-837
• 32 Boey J, Branicki F J, Alagaratnam T T. et al . Proximal gastric vagotomy. The preferred operation for perforations in acute duodenal ulcer.  Ann Surg. 1988;  208 (2) 169-174
• 33 Gisbert J P, Pajares J M. Helicobacter pyloriinfection and gastric outlet obstruction - prevalence of the infection and role of antimicrobial treatment.  Aliment Pharmacol Ther. 2002;  16 (7) 1203-1208
• 34 Brandimarte G, Tursi A, di Cesare L. et al . Antimicrobial treatment for peptic stenosis: a prospective study.  Eur J Gastroenterol Hepatol. 1999;  11 (7) 731-734
• 35 Taskin V, Gurer I, Ozyilkan E. et al . Effect of Helicobacter pylori eradication on peptic ulcer disease complicated with outlet obstruction.  Helicobacter. 2000;  5 (1) 38-40
• 36 Boylan J J, Gradzka M I. Long-term results of endoscopic balloon dilatation for gastric outlet obstruction.  Dig Dis Sci. 1999;  44 (9) 1883-1886
• 37 Hewitt P M, Krige J E, Funnell I C. et al . Endoscopic balloon dilatation of peptic pyloroduodenal strictures.  J Clin Gastroenterol. 1999;  28 (1) 33-35
• 38 Lam Y, Lau J Y, Law K B. et al . Endoscopic balloon dilation and Helicobacter pylori eradication in the treatment of gastric outlet obstruction.  Gastrointest Endosc. 1997;  46 (4) 379-380
• 39 Schilling D, Martin W R, Benz C. et al . Long-term results of endoscopic balloon dilatation of ulcer-induced pyloric stenoses - follow-up of 25 patients.  Z Gastroenterol. 1997;  35 (2) 105-108
• 40 Persson S T, Fraser A G, Lane M R. Long-term follow-up of the management of benign oesophageal strictures at Auckland Hospital 1990-1994.  N Z Med J. 1999;  112 (1081) 28-30