Literatur
-
1
Cassidy J, Twelves C, Van Cutsem E. et al .
First-line oral capacitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with i. v. 5-fluorouracil/leucovorin.
Ann Oncol.
2002;
13
566-575
-
2
Tabernero J, Butts C A, Cassidy J. et al .
Capecitabine and oxaliplatin in combination (Xelox) as first line therapy for patients (pts) with metastatic colorectal cancer (MCRC): results of an international multicenter phase II trial.
Proc Am Soc Clin Oncol.
2002;
21: 133a (Abstr. 531)
-
3
Kerr D J, Ten Bokkel Huinink W W, Ferry D R. et al .
A phase I/II study of CPT-11 in combination with capecitabine as first line chemotherapy for metastatic colorectal cancer (MCRC).
Proc Am Soc Clin Oncol.
2002;
21: 161a (Abstr. 643)
-
4
Burris H A, Moore M J, Andersen J. et al .
Von HDD. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.
J Clin Oncol.
1997;
15
2403-2413
-
5
Cascinu S, Frontini L, Labianca R. et al .
A combination of a fixed dose rate infusion of gemcitabine associated to a bolus 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).
Ann Oncol.
2000;
11
1309-1311
-
6
Di Costanzo F, Sdrobolini A, Carlini P. et al .
Gemcitabine (GEM) Alone or in Combination with 5-FU Continuous Infusion (CI) in the Treatment of Advanced Pancreatic Cancer (APC): a GOIRC Randomized Phase II Trial.
Proc Am Soc Clin Oncol.
2001;
20: 154a (Abstr. 612)
-
7
Wein A, Wehler M, Fischer B. et al .
Phase II study with weekly 24-hour infusion (24-h inf.) of high-dose 5-fluorouracil (5-FU) and gemcitabine (GEM) in metastatic pancreas cancer (UICC IVb): final results.
Proc Am Soc Clin Oncol.
2002;
21: 156a (Abstr. 620)
-
8
Berlin J D, Catalano P, Thomas J P. et al .
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297.
J Clin Oncol.
2002;
20
3270-3275
-
9
Scheithauer W, Schüll B, Ulrich-Pur H. et al .
Gemcitabine alone or in combination with capecitabine in patients with advanced pancreatic adenocarcinoma.
Proc Am Soc Clin Oncol.
2002;
21: 126a (Abstr. 500)
-
10
Rocha L CM, Savarese D, Bruckner H. et al .
Irinotecan plus gemcitabine induces both radiographic and CA 19 - 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer.
J Clin Oncol.
2002;
20
1182-1191
-
11
Lutz M P, Ducreux M, Wagener T. et al .
Docetaxel/gemcitabine or docetaxel/cisplatin in advanced pancreatic carcinoma: a randomized phase II study of the EORTC-GI group.
Proc Am Soc Clin Oncol.
2002;
21: 125a (Abstr. 498)
-
12
Hilgers W, Kern S E.
Molecular genetic basis of pancreatic adenocarcinoma.
Genes, Chromosomes & Cancer.
1999;
26
1-12
-
13
Cunningham D, de Gramont A, Scheithauer W. et al .
Randomized double-blind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colorectal cancer.
Proc Am Soc Clin Oncol.
2002;
21: 126a (Abstr. 502)
-
14
van Cutsem E, Karasek P, Oettle H. et al .
Phase III trial comparing gemcitabine + R115777 (Zarnestra) versus gemcitabine + placebo in advanced pancreatic cancer (PC).
Proc Am Soc Clin Oncol.
2002;
21: 130a (Abstr. 517)
-
15
Blanke C D, Benson A B, Dragovich T. et al .
A phase II trial of celecoxib (CX) irinotecan (I), 5-fluorouracil (5FU), and leucovorin (LCV) in patients (pts) with unresectable or metastatic colorectal cancer (CRC).
Proc Am Soc Clin Oncol.
2002;
21: 127a (Abstr. 505)
-
16
Schmiegel W, Schmielau J, Henne-Bruns D. et al .
Cytokine-mediated enhancement of epidermal growth factor receptor expression provides an immunological approach to the therapy of pancreatic cancer.
Proc Natl Acad Sci USA.
1997;
94
12622-12626
-
17
Bruns C J, Harbison M T, Davis D W. et al .
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical Cancer Research.
2000;
6
1936-1948
-
18
Abbruzzese J L, Rosenberg A, Xiong Q. et al .
Phase II Study of Anti-Epidermal Growth Factor Receptor (EGFR) Antibody Cetuximab (IMC-C225) in Combination with Gemcitabine in Patients with Advanced Pancreatic Cancer.
Proc Am Soc Clin Oncol.
2001;
20: 130a (Abstr. 518)
-
19
Saltz L, Meropol N J, Loehrer P J. et al .
Single agent IMC-225 (Erbitux) has activity in CPT-11-refractory colorectal cancer (CRC) that express the epidermal growth factor receptor (EGF-R).
Proc Am Soc Clin Oncol.
2002;
21: 127a (Abstr. 504)
-
20
Rosenberg A H, Loehrer P F, Needle M N. et al .
Erbitux (IMC-225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that express the epidermal growth factor receptor (EGF-R).
Proc Am Soc Clin Oncol.
2002;
21: 135a (Abstr. 536)
-
21
Safran H, Ramanathan R K, Schwartz J. et al .
Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/neu.
Proc Am Soc Clin Oncol.
2001;
20: 130a (Abstr. 517)
-
22
Ranson M, Hammond L A, Ferry D. et al .
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial.
J Clin Oncol.
2002;
20
2240-2250
-
23
Hidalgo M, Siu L L, Nemunaitis J. et al .
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.
J Clin Oncol.
2001;
19
3267-3279
-
24
von Mehren M, Blanke C, Joensuu H. et al .
High incidence of durable responses induced by imatinib mesylate (Gleevec) in patients with unresectable and metastatic gastrointestinal stromal tumors (GISTs).
Proc Am Soc Clin Oncol.
2002;
21: 403a (Abstract. 1608)
-
25
Heinrich M C, Corless C L, Blanke C. et al .
KIT mutational status predicts clinical response to STI571 in patients with metastatic gastrointestinal stromal tumors (GISTs).
Proc Am Soc Clin Oncol.
2002;
21: 2a (Abstr. 6)
Prof. Dr. med. W. Schmiegel
Medizinische Universitätsklinik, Knappschaftskrankenhaus, Ruhr-Universität Bochum
In der Schornau 23-25
44892 Bochum
Email: med.uni.-kkh@ruhr-uni-bochum.de