Abstract
A conjugate between the cyclic peptide CNGRC and doxorubcin,
previously reported as a ligand of aminopeptidase N (CD13), has
been synthesised and characterised.
Key words
solid-phase synthesis - CNGRC - peptides - doxorubicin - angiogenesis - macrocycles - anti-tumour agents
References 1 Abbreviations: Acm, acetamidomethyl;
DIPEA, N,N -diisopropylethylamine; Fmoc,
9-fluorenylmethoxycarbonyl; HOBt, 1-hydroxybenzotriazole; Pbf, 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl;
PyBOP, benzotriazole-1-yloxytrispyrrolidinophosphonium hexafluorophosphate.
2 Present address: Synthèse
et Etude de Systèmes à Intéret Biologique,
Université Blaise Pascal, UMR 6504, 63177 Aubière,
France.
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