Stellenwert der Hyperthermie für die chirurgische Onkologie

Zusammenfassung

Als Standardtherapie für fortgeschrittene maligne Tumoren hat sich die Durchführung einer Radiochemotherapie etabliert. Um den Effekt dieser Therapie weiter zu verstärken, kann die Kombination mit einer Hyperthermie sinnvoll sein. In dieser Übersichtsarbeit wird die Indikation der Hyperthermie für die chirurgische Onkologie des Gastrointestinaltraktes beschrieben, die derzeit in einigen Zentren in klinischer Anwendung und wissenschaftlicher Beurteilung ist. Insgesamt wurden durch Einbeziehung der Hyperthermie in ein multimodales Behandlungskonzept viel versprechende Ergebnisse erzielt, so dass zur Zeit verschiedene randomisierte Studien durchgeführt werden, die den tatsächlichen Effekt der Hyperthermie als zusätzliches Modul zur Standard-Therapie prüfen.

Abstract

In locally advanced malignant tumors preoperative radiochemotherapy is the current standard therapy for the most entities. Hyperthermia can be applied in combination with this therapeutic regimen to further increase the therapeutic effect. In this review we present the different approaches of hyperthermic therapy that are used in surgical oncology. We focus on the most commonly used forms of hyperthermia according to the gastrointestinal tract. So far, hyperthermia combined with radiochemotherapy led to encouraging results. Randomized trials are warranted to evaluate the real benefit of hyperthermia as compared to radiochemotherapy without hyperthermia.

Regionale Hyperthermie - hypertherme Extremitätenperfusion - Ganzkörperhyperthermie

Regional hyperthermia - hyperthermic limb perfusion - whole body hyperthermia

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