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DOI: 10.1055/s-2002-36343
In Vitro Inhibitory Effect of Rubraxanthone Isolated from Garcinia parvifolia on Platelet-Activating Factor Receptor Binding
Publikationsverlauf
Received: April 5, 2002
Accepted: July 13, 2002
Publikationsdatum:
20. Dezember 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200212/lookinside/thumbnails/10.1055-s-2002-36343-1.jpg)
Abstract
Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3 H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC50 value of 18.2 μM. The IC50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6′-dimethylpyrano(2′,3′:6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor.
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Ibrahim Jantan, PhD
Department of Pharmacy
Faculty of Allied Health Sciences
Universiti Kebangsaan Malaysia
Jalan Raja Muda Abdul Aziz
50300 Kuala Lumpur
Malaysia
Telefon: +603-40405331
Fax: +603-26983271
eMail: ibj@medic.ukm.my