Antibacterial Activity of a Stearic Acid Derivative from Stemodia foliosa

Abstract

From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10 μg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.

References

• 1 Barroso G. Sistemática de Angiospermas do Brasil. Vol. 3 Viçosa; Universidade Federal de Viçosa 1991: 124-30
• 2 Chamy M C, Piovano M, Garbarino J A, Gambaro V. Stemodane diterpenoids from Stemodia chilensis .  Phytochemistry. 1991;  30 1719-21
• 3 Hufford C D. H-1-NMR and C-13-NMR Assignments for the Stemodia diterpenes stemodin, stemodinone and maritimol.  J Nat Prod. 1988;  51 367-9
• 4 Weniger B, Haagberrurier M, Anton R. Plants of Haiti used as antifertility agents.  J Ethnopharmacol. 1982;  6 67-84
• 5 Correa M P. Dicionário das Plantas Úteis do Brasil e das Exóticas Cultivadas. Rio de Janeiro; Ministério da Agricultura, IBDF 1978: 182-97
• 6 Watt B, Collee J G. Bacterial challenges and evolving antibacterial drug strategy.  Postgrad Med J. 1992;  68 6-21
• 7 National Committee for Clinical Laboratory Standards, 3^rd. ed., Approved Standard M7-A3, NCCLS, Villanova, PA. 1993
• 8 Holland H L, Diakow P RP, Taylor G J. C-13 Nuclear magnetic-resonance spectra of some C-19-hydroxy, C-5,6 epoxy, C-24 ethyl, and C-19-norsteroids.  Can. J. Chem.. 1978;  56 3121-7
• 9 Mahato S B, Kundu A P. C-13 NMR spectra of pentacyclic triterpenoids - A compilation and some salient features.  Phytochemistry. 1994;  37 1517-75